{"doi":"10.1101/2021.08.02.453806","title":"The CHK-2 antagonizing phosphatase PPM-1.D regulates meiotic entry via catalytic and non-catalytic activities","abstract":"Summary The transition from the stem cell/progenitor fate to meiosis is mediated by several redundant post-transcriptional regulatory pathways in C. elegans . Interfering with all three branches causes tumorous germlines. SCF PROM-1 comprises one branch and mediates a scheduled degradation step at entry into meiosis. prom-1 mutants show defects in timely initiation of events of meiotic prophase I, resulting in high rates of embryonic lethality. Here, we identify the phosphatase PPM-1.D/Wip1 as crucial substrate for PROM-1. We report that PPM-1.D antagonizes CHK-2 kinase, a key regulator for meiotic prophase initiation e.g., DNA double strand breaks, chromosome pairing and synaptonemal complex formation. We propose that PPM-1.D controls the amount of active CHK-2 by both catalytic and non-catalytic activities, where strikingly the non-catalytic regulation seems to be crucial at meiotic entry. PPM-1.D sequesters CHK-2 at the nuclear periphery and programmed SCF PROM-1 mediated degradation of PPM-1.D liberates the kinase and promotes meiotic entry.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2021,"id":216747,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9513,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":470298,"name":"Dimitra Paouneskou","orcid":"0009-0007-5942-1829","position":1,"is_corresponding":false},{"id":348754,"name":"Ariz Mohammad","orcid":"0000-0002-2807-412X","position":2,"is_corresponding":false},{"id":813708,"name":"Raffael Lichtenberger","orcid":null,"position":3,"is_corresponding":false},{"id":813029,"name":"Joshua Blundon","orcid":"0009-0009-8412-6818","position":4,"is_corresponding":false},{"id":302749,"name":"Yumi Kim","orcid":"0000-0002-6110-5936","position":5,"is_corresponding":false},{"id":114373,"name":"Markus Hartl","orcid":"0000-0002-4970-7336","position":6,"is_corresponding":false},{"id":813030,"name":"Sebastian Falk","orcid":"0000-0001-7848-4621","position":7,"is_corresponding":false},{"id":246656,"name":"Tim Schedl","orcid":"0000-0003-2148-2996","position":8,"is_corresponding":false},{"id":468237,"name":"Verena Jantsch","orcid":"0000-0002-1978-682X","position":9,"is_corresponding":false},{"id":468235,"name":"Antoine Baudrimont","orcid":"0000-0001-9410-6356","position":0,"is_corresponding":true}],"reference_count":74,"raw_metadata":null,"created_at":"2026-07-18T23:53:15.868165Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}