{"doi":"10.1101/2021.07.28.454109","title":"miR-17∼92 exerts stage-specific effects in adult V-SVZ neural stem cell lineages","abstract":"Summary In the adult mouse brain, neural stem cells (NSCs) in the ventricular-subventricular zone (V-SVZ) generate neurons and glia throughout life. microRNAs are important regulators of cell states, frequently acting in a stage- or context-dependent manner. Here, miRNA profiling of FACS-purified populations identified miR-17∼92 as highly upregulated in activated NSCs and transit amplifying cells (TACs) in comparison to quiescent NSCs. Conditional deletion of miR-17∼92 in NSCs reduced stem cell proliferation both in vitro and in vivo . In contrast, in TACs, miR-17∼92 deletion caused a selective shift from neurogenic DLX2 + TACs towards oligodendrogenic OLIG2 + TACs, resulting in increased oligodendrogenesis to the corpus callosum . miR-17∼92 deletion also decreased proliferation and maturation of intraventricular oligodendrocyte progenitor cells. Together, these findings reveal stage- and cell-type-specific functions of the miR-17∼92 cluster within adult V-SVZ neural stem cell lineages.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2021,"id":225834,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9514,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":248804,"name":"Annina M. DeLeo","orcid":null,"position":1,"is_corresponding":false},{"id":641913,"name":"Ana C. Delgado","orcid":"0000-0002-8116-6461","position":2,"is_corresponding":false},{"id":641920,"name":"Fiona Doetsch","orcid":"0000-0002-0577-1272","position":3,"is_corresponding":false},{"id":828926,"name":"Fabrizio Favaloro","orcid":null,"position":0,"is_corresponding":true}],"reference_count":63,"raw_metadata":null,"created_at":"2026-07-18T23:54:30.292454Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}