{"doi":"10.1101/2021.07.19.452945","title":"TGF-β-dependent Lymphoid Tissue Residency of Stem-like T cells Limits the Response to Tumor Vaccine","abstract":"Abstract Stem-like CD8 + T cells represent the key subset responding to multiple tumor immunotherapies, including tumor vaccination. However, the signals that control the differentiation of stem-like T cells are not entirely known. Most previous investigations on stem-like T cells are focused on tumor infiltrating T cells (TIL). The behavior of stem-like T cells in other tissues remains to be elucidated. Tissue-resident memory T cells (T RM ) are often defined as a non-circulating T cell population residing in non-lymphoid tissues. TILs carrying T RM features are associated with better tumor control. Here, we found that stem-like CD8 + T cells differentiated into T RM s in a TGF-β and tumor antigen dependent manner almost exclusively in tumor draining lymph node (TDLN). TDLN-resident stemlike T cells were negatively associated with the response to tumor vaccine. In other words, after tumor vaccine, TDLN stem-like T cells transiently lost T RM features, differentiated into migratory effectors and exerted tumor control.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2021,"id":225844,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9517,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":725836,"name":"Liwen Wang","orcid":"0000-0003-1239-4927","position":1,"is_corresponding":false},{"id":315978,"name":"Chaoyu Ma","orcid":null,"position":2,"is_corresponding":false},{"id":314396,"name":"Wei Liao","orcid":"0000-0002-8828-011X","position":3,"is_corresponding":false},{"id":828591,"name":"Yong Liu","orcid":"0000-0002-5208-888X","position":4,"is_corresponding":false},{"id":314395,"name":"Shruti Mishra","orcid":"0000-0001-8055-1475","position":5,"is_corresponding":false},{"id":314400,"name":"Xin Zhang","orcid":"0000-0002-9273-6212","position":6,"is_corresponding":false},{"id":314401,"name":"Yuanzheng Qiu","orcid":"0000-0001-9518-388X","position":7,"is_corresponding":false},{"id":828592,"name":"Qianjin Lu","orcid":"0000-0002-4192-4897","position":8,"is_corresponding":false},{"id":256588,"name":"Nu Zhang","orcid":"0000-0001-9695-210X","position":9,"is_corresponding":false},{"id":607674,"name":"Guo Li","orcid":"0000-0001-7133-7557","position":0,"is_corresponding":true}],"reference_count":64,"raw_metadata":null,"created_at":"2026-07-18T23:54:30.292454Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}