{"doi":"10.1101/2021.07.16.452724","title":"Novel Hendra virus variant detected by sentinel surveillance of Australian horses","abstract":"Abstract A novel Hendra virus (HeV) variant, not detected by routine testing, was identified and isolated from a Queensland horse that suffered acute, fatal disease consistent with HeV infection. Whole genome sequencing and phylogenetic analysis demonstrated the variant to have ~83% nucleotide identity to the prototype HeV strain. An updated RT-qPCR assay was designed for routine HeV surveillance. In silico and in vitro comparison of the receptor-binding protein with prototypic HeV showed that the human monoclonal antibody m102.4 used for post-exposure prophylaxis, as well as the current equine vaccine, should be effective against this variant. Genetic similarity of this virus to sequences detected from grey-headed flying-foxes suggests the variant circulates at-least in this species. Studies determining infection kinetics, pathogenicity, reservoir-species associations, viral–host co-evolution and spillover dynamics for this virus are urgently needed. Surveillance and biosecurity practices should be updated to appreciate HeV spillover risk across all regions frequented by flying foxes.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2021,"id":215509,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9483,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":714460,"name":"Bethany A. 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Singanallur","orcid":"0000-0002-0523-3853","position":11,"is_corresponding":false},{"id":810255,"name":"Karren M. Plain","orcid":"0000-0001-7126-9865","position":12,"is_corresponding":false},{"id":810256,"name":"Karan Kim","orcid":"0000-0003-3898-3308","position":13,"is_corresponding":false},{"id":347528,"name":"Mary Tachedjian","orcid":"0000-0002-8936-6564","position":14,"is_corresponding":false},{"id":810823,"name":"Brenda van der Heide","orcid":null,"position":15,"is_corresponding":false},{"id":810257,"name":"Sandra Crameri","orcid":"0000-0003-3284-3355","position":16,"is_corresponding":false},{"id":810258,"name":"David T. Williams","orcid":"0000-0002-7169-149X","position":17,"is_corresponding":false},{"id":810259,"name":"Cristy Secombe","orcid":"0000-0003-2268-1452","position":18,"is_corresponding":false},{"id":533696,"name":"Eric D. Laing","orcid":"0000-0002-5574-2584","position":19,"is_corresponding":false},{"id":551666,"name":"Spencer L. 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