{"doi":"10.1101/2021.07.14.452366","title":"Ing4-deficiency enhances HSC quiescence and confers resistance to inflammatory stress","abstract":"Abstract Hematopoiesis is tightly regulated by a network of transcription factors and complexes that are required for the development and maintenance of hematopoietic stem cells (HSCs). We recently identified the tumor suppressor, Ing4, as a critical regulator of HSC homeostasis. Though the Ing4 mechanism of action remains poorly characterized, it has been shown to promote stem-like cell characteristics in malignant cells. This activity is, in part, due to Ing4 mediated regulation of several major signaling pathways, including NF-κB and c-Myc. In murine hematopoiesis, Ing4 deficiency induces G 0 arrest in HSCs, while simultaneously promoting gene expression signatures associated with differentiation. This results in a poised state for Ing4-deficient HSCs. Long term HSCs are unable to overcome this block, but short-term HSCs convert the poised state into regenerative capacity during hematopoietic challenges, including irradiation and transplantation. Overall, our findings suggest that Ing4 plays a crucial role in the regulation of hematopoiesis. Our model provides key tools for further identification and characterization of pathways that control quiescence and differentiation in HSCs.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2021,"id":225700,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9526,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":828430,"name":"Georgina A. Anderson","orcid":"0000-0003-3850-1583","position":1,"is_corresponding":false},{"id":828431,"name":"Melanie Rodriguez","orcid":"0000-0002-1599-2079","position":2,"is_corresponding":false},{"id":828841,"name":"Seth Gabriel","orcid":null,"position":3,"is_corresponding":false},{"id":828842,"name":"Vera Binder","orcid":null,"position":4,"is_corresponding":false},{"id":69693,"name":"Alison M. Taylor","orcid":"0000-0001-9341-535X","position":5,"is_corresponding":false},{"id":503536,"name":"Katie L. Kathrein","orcid":"0000-0002-5903-6388","position":6,"is_corresponding":false},{"id":828840,"name":"Zanshé Thompson","orcid":null,"position":0,"is_corresponding":true}],"reference_count":75,"raw_metadata":null,"created_at":"2026-07-18T23:54:30.292454Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}