{"doi":"10.1101/2021.07.08.21260222","title":"Modulation of a Stable Neurobehavioral Trait Using Repetitive Transcranial Magnetic Stimulation: A Preregistered Randomized Controlled Trial","abstract":"ABSTRACT Hypnotizability, one’s ability to experience cognitive, emotional, behavioral, and physical changes in response to suggestions in the context of hypnosis, is a highly stable trait associated with increased functional connectivity between the left dorsolateral prefrontal cortex (L-DLPFC) and dorsal anterior cingulate cortex (dACC). We conducted a preregistered, triple-blinded, randomized controlled trial to test the ability of continuous theta-burst stimulation (cTBS) over a personalized neuroimaging-based L-DLPFC target to temporarily enhance hypnotizability. We tested our hypothesis in 78 patients with fibromyalgia syndrome (FMS), a functional pain disorder for which hypnosis has consistently been shown to be beneficial as a nonpharmacological treatment option. Pre-to-post cTBS change in Hypnotic Induction Profile scores (HIP; a standardized measure of hypnotizability) was significantly greater in the Active versus Sham group. Our findings suggest a causal relationship between L-DLPFC and dACC function and hypnotizability. Dose-response optimization should be further examined to formalize guidelines for future clinical utilization. Trial registration ClinicalTrials.gov NCT02969707","journal":"medRxiv","year":2021,"id":215505,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9488,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":810244,"name":"James H. Bishop","orcid":"0000-0001-6106-2764","position":1,"is_corresponding":false},{"id":95845,"name":"Katy H. Stimpson","orcid":"0000-0001-5919-9673","position":2,"is_corresponding":false},{"id":670464,"name":"Angela Phillips","orcid":"0000-0002-7911-1808","position":3,"is_corresponding":false},{"id":810245,"name":"M. Gulser","orcid":"0000-0003-3659-1853","position":4,"is_corresponding":false},{"id":810815,"name":"Heer Amin","orcid":null,"position":5,"is_corresponding":false},{"id":237013,"name":"Romina Nejad","orcid":"0000-0003-1391-1041","position":6,"is_corresponding":false},{"id":95851,"name":"Danielle D. DeSouza","orcid":"0000-0001-6861-5691","position":7,"is_corresponding":false},{"id":810246,"name":"Andrew Geoly","orcid":"0000-0002-3483-026X","position":8,"is_corresponding":false},{"id":294218,"name":"Elisa Kallioniemi","orcid":"0000-0001-6706-2837","position":9,"is_corresponding":false},{"id":263618,"name":"Booil Jo","orcid":"0000-0001-8855-147X","position":10,"is_corresponding":false},{"id":95860,"name":"Nolan Williams","orcid":"0000-0003-4368-3203","position":11,"is_corresponding":false},{"id":425960,"name":"David Spiegel","orcid":"0000-0002-9476-9173","position":12,"is_corresponding":false},{"id":490881,"name":"Afik Faerman","orcid":"0000-0001-7140-8204","position":0,"is_corresponding":true}],"reference_count":66,"raw_metadata":null,"created_at":"2026-07-18T23:52:55.971300Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}