{"doi":"10.1101/2021.07.08.21260162","title":"Immunogenicity of Oxford-AstraZeneca COVID-19 vaccine in Vietnamese healthcare workers","abstract":"ABSTRACT We studied the immunogenicity of Oxford-AstraZeneca vaccine in Vietnamese healthcare workers. We collected blood samples before each dose, at 14 days after each dose, and month 1 and 3 after dose 1 from each participant alongside demographics data. We measured neutralizing antibodies using a surrogate virus neutralization assay. The 554 study participants (136 males and 418 females) were aged between 22-71 years (median: 36 years). 104 and 94 out of 144 selected participants were successfully followed up at 14 days after dose 2 and 3 months after dose 1, respectively. Neutralizing antibodies increased after each dose, with the sero-conversion rate reaching 98.1% (102/104) at 14 days after dose 2. At month 3 after dose 1, neutralizing antibody levels decreased, while 94.7% (89/94) of the study participants remained seropositive. Oxford-AstraZeneca COVID-19 vaccine is immunogenic in Vietnamese healthcare workers. The requirement for a third dose warrants further research.","journal":"medRxiv","year":2021,"id":217628,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9488,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":637502,"name":"Lam Anh Nguyet","orcid":null,"position":1,"is_corresponding":false},{"id":637522,"name":"Nguyen Thanh Truong","orcid":null,"position":2,"is_corresponding":false},{"id":637505,"name":"Le Mau Toan","orcid":null,"position":3,"is_corresponding":false},{"id":636666,"name":"Nguyen Thanh Dung","orcid":"0000-0001-9635-1136","position":4,"is_corresponding":false},{"id":637521,"name":"Le Manh Hung","orcid":null,"position":5,"is_corresponding":false},{"id":814911,"name":"Mai Thanh Nhan","orcid":null,"position":6,"is_corresponding":false},{"id":637517,"name":"Dinh Nguyen Huy Man","orcid":null,"position":7,"is_corresponding":false},{"id":637501,"name":"Nghiêm My Ngoc","orcid":null,"position":8,"is_corresponding":false},{"id":636661,"name":"Huynh Phuong Thao","orcid":"0000-0001-6387-8820","position":9,"is_corresponding":false},{"id":637520,"name":"Tran Nguyen Hoang Tu","orcid":null,"position":10,"is_corresponding":false},{"id":731134,"name":"Huynh Kim","orcid":"0000-0002-8209-5677","position":11,"is_corresponding":false},{"id":731842,"name":"Do Thai Hung","orcid":null,"position":12,"is_corresponding":false},{"id":636656,"name":"Nguyen Thi Han Ny","orcid":"0000-0002-9833-2921","position":13,"is_corresponding":false},{"id":814912,"name":"Le Kim Thanh","orcid":null,"position":14,"is_corresponding":false},{"id":636664,"name":"Nguyen To Anh","orcid":"0000-0001-8814-4436","position":15,"is_corresponding":false},{"id":636658,"name":"Nguyen Thi Thu Hong","orcid":"0000-0002-4103-2450","position":16,"is_corresponding":false},{"id":636660,"name":"Le Nguyen Truc Nhu","orcid":"0000-0002-7685-9730","position":17,"is_corresponding":false},{"id":636665,"name":"Lam Minh Yen","orcid":"0000-0002-5126-110X","position":18,"is_corresponding":false},{"id":636663,"name":"Marc Choisy","orcid":"0000-0002-5187-6390","position":19,"is_corresponding":false},{"id":636667,"name":"Tran Tan Thanh","orcid":"0000-0002-8096-7750","position":20,"is_corresponding":false},{"id":320907,"name":"Guy Thwaites","orcid":"0000-0002-2858-2087","position":21,"is_corresponding":false},{"id":305632,"name":"Le Van Tan","orcid":"0000-0002-1791-3901","position":22,"is_corresponding":false},{"id":637500,"name":"Nguyen Van Vinh Chau","orcid":null,"position":0,"is_corresponding":true}],"reference_count":17,"raw_metadata":null,"created_at":"2026-07-18T23:53:20.374789Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}