{"doi":"10.1101/2021.07.02.450857","title":"Dasabuvir inhibits human norovirus infection in human intestinal enteroids","abstract":"Abstract Human noroviruses (HuNoVs) are acute viral gastroenteritis pathogens that affect all age groups, yet no approved vaccines and drugs to treat HuNoV infection are available. In this study, with a human intestinal enteroid (HIE) culture system where HuNoVs are able to replicate reproducibly, we screened an antiviral compound library to identify compound(s) showing anti-HuNoV activity. Dasabuvir, which has been developed as an anti-hepatitis C virus agent, was found to inhibit HuNoV infection in HIEs at micromolar concentrations. Dasabuvir also inhibited severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human A rotavirus (RVA) infection in HIEs. To our knowledge, this is the first study to screen an antiviral compound library for HuNoV using HIEs and we successfully identified dasabuvir as a novel anti-HuNoV inhibitor that warrants further investigation.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2021,"id":225667,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9547,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":270530,"name":"Kosuke Murakami","orcid":"0000-0002-1712-7433","position":1,"is_corresponding":false},{"id":828386,"name":"Junki Hirano","orcid":"0009-0003-9254-8937","position":2,"is_corresponding":false},{"id":828387,"name":"Yoshiki Fujii","orcid":"0000-0002-4519-0309","position":3,"is_corresponding":false},{"id":828388,"name":"Yoko Yamaoka","orcid":"0000-0002-7568-3489","position":4,"is_corresponding":false},{"id":828389,"name":"Hirofumi Ohashi","orcid":"0009-0008-2709-3186","position":5,"is_corresponding":false},{"id":392332,"name":"Koichi Watashi","orcid":"0000-0002-4536-9966","position":6,"is_corresponding":false},{"id":270540,"name":"Mary K. Estes","orcid":"0000-0002-4813-4249","position":7,"is_corresponding":false},{"id":392341,"name":"Masamichi Muramatsu","orcid":"0000-0002-0153-3533","position":8,"is_corresponding":false},{"id":483518,"name":"Tsuyoshi Hayashi","orcid":"0000-0003-3158-673X","position":0,"is_corresponding":true}],"reference_count":25,"raw_metadata":null,"created_at":"2026-07-18T23:54:30.292454Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}