{"doi":"10.1101/2021.06.30.449753","title":"Epigenetic regulation clocks the multigenerational olfactory imprinting in <i>C. elegans</i>","abstract":"Abstract Imprinting is an early sensory life experience that induces adult behaviours, such as mother recognition or homing. In a previous study, we demonstrated a striking olfactory imprinting in C. elegans that can be inherited over generations. When exposed to specific odorants during a timely controlled post-hatch period, C. elegans worms display during adulthood an enhanced migration towards these molecules. In order to unveil some of the genetic and epigenetic factors that are responsible for such a behavioural plasticity, we assessed the role of heterochronic genes using a candidate gene approach. We report here that translation of the Hunchback-Like 1 (HBL1) transcription factor in the sensory processing interneuron AIY, is a determining factor for olfactory plasticity timing in C . elegans . HBL1 may associate to the SPR1/CoREST co-repressor, the lysine demethylase SPR5/LSD1 and the histone deacetylase HDA3 to lengthen the plasticity period, whereas the translation initiation factor IFE-4 and the histone deacetylase HDA2 abridge it. We also observed that lengthened plasticity periods allow proportionally faster stable behavioral adaptation of C. elegans populations. We conclude that plasticity timing is a key factor, not only to transiently adapt individuals but also to stably adapt animal populations via multigenerational accumulation of experience.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2021,"id":219032,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9477,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":817582,"name":"Diana Andrea Fernandes de Abreu","orcid":null,"position":1,"is_corresponding":false},{"id":817168,"name":"Antoine Gruet","orcid":"0000-0001-5000-7903","position":2,"is_corresponding":false},{"id":817169,"name":"Marie‐Pierre Blanchard","orcid":"0000-0002-4063-4070","position":3,"is_corresponding":false},{"id":817170,"name":"Kévin Baranger","orcid":"0000-0001-8206-8874","position":4,"is_corresponding":false},{"id":817583,"name":"Yoanne M. Clovis","orcid":null,"position":5,"is_corresponding":false},{"id":817171,"name":"François Féron","orcid":"0000-0002-5757-7615","position":6,"is_corresponding":false},{"id":817584,"name":"Jean‐Jacques Rémy","orcid":null,"position":7,"is_corresponding":false},{"id":817167,"name":"Madeleine Erard-Garcia","orcid":"0000-0002-0618-706X","position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":null,"created_at":"2026-07-18T23:53:33.915158Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}