{"doi":"10.1101/2021.06.07.447286","title":"Dual roles of a novel oncolytic viral vector-based SARS-CoV-2 vaccine: preventing COVID-19 and treating tumor progression","abstract":"The ongoing coronavirus disease 2019 (COVID-19) pandemic is caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Cancer patients are usually immunocompromised and thus are particularly susceptible to SARS-CoV-2 infection resulting in COVID-19. Although many vaccines against COVID-19 are being preclinically or clinically tested or approved, none have yet been specifically developed for cancer patients or reported as having potential dual functions to prevent COVID-19 and treat cancer. Here, we confirmed that COVID-19 patients with cancer have low levels of antibodies against the spike (S) protein, a viral surface protein mediating the entry of SARS-CoV-2 into host cells, compared with COVID-19 patients without cancer. We developed an oncolytic herpes simplex virus-1 vector-based vaccine named oncolytic virus (OV)-spike. OV-spike induced abundant anti-S protein neutralization antibodies in both tumor-free and tumor-bearing mice, which inhibit infection of VSV-SARS-CoV-2 and wild-type (WT) live SARS-CoV-2 as well as the B.1.1.7 variant in vitro. In the tumor-bearing mice, OV-spike also inhibited tumor growth, leading to better survival in multiple preclinical tumor models than the untreated control. Furthermore, OV-spike induced anti-tumor immune response and SARS-CoV-2-specific T cell response without causing serious adverse events. Thus, OV-spike is a promising vaccine candidate for both preventing COVID-19 and enhancing the anti-tumor response. ONE SENTENCE SUMMARY: A herpes oncolytic viral vector-based vaccine is a promising vaccine with dual roles in preventing COVID-19 and treating tumor progression.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2021,"id":215978,"datarank":0.26876392038420827,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.0,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9516,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":374844,"name":"Wenjuan Dong","orcid":"0000-0002-4110-424X","position":1,"is_corresponding":false},{"id":622921,"name":"Lei Tian","orcid":"0000-0002-5609-0098","position":2,"is_corresponding":false},{"id":678828,"name":"Youliang Rao","orcid":"0000-0002-8416-8104","position":3,"is_corresponding":false},{"id":678826,"name":"Chao Qin","orcid":"0000-0003-0393-1751","position":4,"is_corresponding":false},{"id":576454,"name":"Sierra A. Jaramillo","orcid":null,"position":5,"is_corresponding":false},{"id":482796,"name":"Erik W. Settles","orcid":"0000-0003-4331-3683","position":6,"is_corresponding":false},{"id":622923,"name":"Shoubao Ma","orcid":"0000-0002-7067-3599","position":7,"is_corresponding":false},{"id":374845,"name":"Jianying Zhang","orcid":"0000-0001-5896-9509","position":8,"is_corresponding":false},{"id":811304,"name":"Yu Kang","orcid":"0000-0001-5196-0376","position":9,"is_corresponding":false},{"id":622922,"name":"Bo Xu","orcid":"0009-0001-4690-4414","position":10,"is_corresponding":false},{"id":623297,"name":"Jiazhuo Yan","orcid":"0000-0001-9233-7185","position":11,"is_corresponding":false},{"id":622918,"name":"Rui Ma","orcid":"0009-0003-3969-1283","position":12,"is_corresponding":false},{"id":1643,"name":"Zhuo Li","orcid":"0000-0002-8184-6678","position":13,"is_corresponding":false},{"id":275260,"name":"Sanjeet Dadwal","orcid":"0000-0002-1099-0568","position":14,"is_corresponding":false},{"id":316384,"name":"Bridget M. Barker","orcid":"0000-0002-3439-4517","position":15,"is_corresponding":false},{"id":380251,"name":"Paul Keim","orcid":"0000-0003-0089-5820","position":16,"is_corresponding":false},{"id":180721,"name":"Pinghui Feng","orcid":null,"position":17,"is_corresponding":false},{"id":3645,"name":"Michael A. Caligiuri","orcid":"0000-0002-4095-3020","position":18,"is_corresponding":false},{"id":253516,"name":"Jianhua Yu","orcid":"0000-0002-0326-3223","position":19,"is_corresponding":false},{"id":335071,"name":"Yaping Sun","orcid":"0000-0002-3476-7280","position":0,"is_corresponding":true}],"reference_count":45,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:53:00.192353Z","pmid":"34127971","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}