{"doi":"10.1101/2021.05.26.445616","title":"TIGER: The gene expression regulatory variation landscape of human pancreatic islets","abstract":"Abstract GWAS have identified more than 700 genetic signals associated with type 2 diabetes (T2D). To gain insight into the underlying molecular mechanisms, we created the Translational human pancreatic Islet Genotype tissue-Expression Resource (TIGER), aggregating >500 human islet RNA-seq and genotyping datasets. We imputed genotypes using 4 reference panels and meta-analyzed cohorts to improve coverage of expression quantitative trait loci (eQTL) and developed a method to combine allele-specific expression across samples (cASE). We identified >1 million islet eQTLs (56% novel), of which 53 colocalize with T2D signals (60% novel). Among them, a low-frequency allele that reduces T2D risk by half increases CCND2 expression. We identified 8 novel cASE colocalizations, among which an SLC30A8 T2D associated variant. We make all the data available through the open-access TIGER portal ( http://tiger.bsc.es ), which represents a comprehensive human islet genomic data resource to elucidate how genetic variation affects islet function and translate this into therapeutic insight and precision medicine for T2D.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2021,"id":214909,"datarank":0.41469823482768753,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.08511454822725455,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.08511454822725455,"corpus_percentile":55.40341920012377,"corpus_rank":5766,"citation_count":8,"citer_count":5,"citers_with_citation_signal":5,"citers_with_endowment":5,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.947,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":636453,"name":"Anthony Piron","orcid":"0000-0002-7931-3784","position":1,"is_corresponding":false},{"id":499615,"name":"Ignasi Morán","orcid":"0000-0002-3307-7106","position":2,"is_corresponding":false},{"id":499619,"name":"Marta Guindo-Martínez","orcid":"0000-0002-8099-9170","position":3,"is_corresponding":false},{"id":556042,"name":"Sílvia Bonàs‐Guarch","orcid":"0000-0002-2085-7488","position":4,"is_corresponding":false},{"id":636454,"name":"Goutham Atla","orcid":"0000-0002-4221-6251","position":5,"is_corresponding":false},{"id":246536,"name":"Irene Miguel-Escalada","orcid":"0000-0003-3461-6404","position":6,"is_corresponding":false},{"id":13987,"name":"Romina Royo","orcid":"0000-0003-3493-0874","position":7,"is_corresponding":false},{"id":13943,"name":"Montserrat Puiggròs","orcid":"0000-0001-5034-7924","position":8,"is_corresponding":false},{"id":570251,"name":"Javier García-Hurtado","orcid":"0000-0001-5271-3107","position":9,"is_corresponding":false},{"id":636455,"name":"Mara Suleiman","orcid":"0000-0002-2478-8782","position":10,"is_corresponding":false},{"id":262815,"name":"Lorella Marselli","orcid":"0000-0002-6698-2962","position":11,"is_corresponding":false},{"id":636456,"name":"Jonathan L.S. Esguerra","orcid":"0000-0001-8454-6606","position":12,"is_corresponding":false},{"id":262808,"name":"Jean‐Valéry Turatsinze","orcid":"0000-0001-9492-6274","position":13,"is_corresponding":false},{"id":467050,"name":"Jason Torres","orcid":"0000-0002-7537-7035","position":14,"is_corresponding":false},{"id":254924,"name":"Vibe Nylander","orcid":"0000-0003-1511-373X","position":15,"is_corresponding":false},{"id":255703,"name":"Xi Chen","orcid":"0000-0001-6974-4321","position":16,"is_corresponding":false},{"id":636458,"name":"Lena Eliasson","orcid":"0000-0002-6467-5029","position":17,"is_corresponding":false},{"id":355579,"name":"Matthieu Defrance","orcid":"0000-0002-3090-3142","position":18,"is_corresponding":false},{"id":556041,"name":"Ramon Amela","orcid":"0000-0001-5943-5824","position":19,"is_corresponding":false},{"id":809652,"name":"MAGIC","orcid":null,"position":20,"is_corresponding":false},{"id":636459,"name":"Hindrik Mulder","orcid":"0000-0002-6593-8417","position":21,"is_corresponding":false},{"id":7383,"name":"Anna L. Gloyn","orcid":"0000-0003-1205-1844","position":22,"is_corresponding":false},{"id":1063,"name":"Leif Groop","orcid":"0000-0002-0187-3263","position":23,"is_corresponding":false},{"id":262816,"name":"Piero Marchetti","orcid":"0000-0003-4907-0635","position":24,"is_corresponding":false},{"id":262820,"name":"Décio L. Eizirik","orcid":"0000-0003-2453-5889","position":25,"is_corresponding":false},{"id":246537,"name":"Jorge Ferrer","orcid":"0000-0002-5959-5729","position":26,"is_corresponding":false},{"id":253982,"name":"Josep M. Mercader","orcid":"0000-0001-8494-3660","position":27,"is_corresponding":false},{"id":33732,"name":"Miriam Cnop","orcid":"0000-0002-5112-1692","position":28,"is_corresponding":false},{"id":14144,"name":"David Torrents","orcid":"0000-0002-6086-9037","position":29,"is_corresponding":false},{"id":499617,"name":"Lorena Alonso","orcid":"0000-0003-3392-5133","position":0,"is_corresponding":true}],"reference_count":68,"raw_metadata":null,"created_at":"2026-07-18T23:52:51.201033Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}