{"doi":"10.1101/2021.05.16.444387","title":"Slow Cortical Waves through Cyclicity Analysis","abstract":"Abstract Fine-grained understanding of dynamics in cortical networks is crucial in unpacking brain function. Here, we introduce a novel analytical method to characterize the dynamic interaction between distant brain regions, and apply it to data from the Human Connectome Project. Resting-state fMRI results in time series recordings of the activity of different brain regions, which are aperiodic and lacking a base frequency. Cyclicity Analysis, a novel technique robust with respect to time-reparametrizations, is effective in recovering temporal ordering of such time series along a circular trajectory without assuming any time-scale. Our analysis detected slow cortical waves of activity propagating across the brain with consistent lead-lag relationships between specific brain regions. We also observed short bursts of task-modulated strong temporal ordering that dominate overall lead-lag relationships between pairs of regions in the brain. Our results suggest the possible role played by slow waves of information transmission between brain regions that underlie emergent cognitive function.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2021,"id":217426,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.952,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":814294,"name":"Somayeh Shahsavarani","orcid":"0000-0002-7468-9707","position":1,"is_corresponding":false},{"id":426563,"name":"Benjamin Zimmerman","orcid":"0000-0003-2570-8198","position":2,"is_corresponding":false},{"id":587859,"name":"Fatima T. Husain","orcid":"0000-0001-5878-3851","position":3,"is_corresponding":false},{"id":814295,"name":"Yuliy Baryshnikov","orcid":"0000-0003-4801-173X","position":4,"is_corresponding":false},{"id":814293,"name":"Ivan Abraham","orcid":"0000-0002-3350-7620","position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:53:20.374789Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}