{"doi":"10.1101/2021.05.06.442992","title":"Neuronal GPCR regulates the specificity of innate immunity against pathogen infection","abstract":"Summary A key question in current immunology is how the innate immune system generates high levels of specificity. Using the Caenorhabditis elegans model system, we demonstrate that functional loss of NMUR-1, a neuronal G protein-coupled receptor homologous to mammalian receptors for the neuropeptide neuromedin U, has diverse effects on C. elegans innate immunity against various bacterial pathogens. Transcriptomic analyses and functional assays revealed that NMUR-1 modulates C. elegans transcription activity by regulating the expression of transcription factors involved in binding to RNA polymerase II regulatory regions, which, in turn, controls the expression of distinct immune genes in response to different pathogens. These results uncovered a molecular basis for the specificity of C. elegans innate immunity. Given the evolutionary conservation of NMUR-1 signaling in immune regulation across multicellular organisms, our study could provide mechanistic insights into understanding the specificity of innate immunity in other animals, including mammals.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2021,"id":224007,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9485,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":820943,"name":"Shawndra Wibisono","orcid":null,"position":1,"is_corresponding":false},{"id":325281,"name":"Jan Watteyne","orcid":"0000-0002-9106-6712","position":2,"is_corresponding":false},{"id":297113,"name":"Chia-Hui Chen","orcid":null,"position":3,"is_corresponding":false},{"id":652271,"name":"Durai Sellegounder","orcid":"0000-0002-0776-0307","position":4,"is_corresponding":false},{"id":325291,"name":"Isabel Beets","orcid":"0000-0002-0968-4360","position":5,"is_corresponding":false},{"id":388866,"name":"Yiyong Liu","orcid":"0000-0002-5112-2871","position":6,"is_corresponding":false},{"id":388867,"name":"Jingru Sun","orcid":"0000-0003-1901-5600","position":7,"is_corresponding":false},{"id":388865,"name":"Phillip Wibisono","orcid":"0000-0001-9166-8556","position":0,"is_corresponding":true}],"reference_count":54,"raw_metadata":null,"created_at":"2026-07-18T23:54:14.760456Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}