{"doi":"10.1101/2021.05.06.442934","title":"The miR-424/503 cluster modulates Wnt/β-catenin signaling in the mammary epithelium by regulating the expression of the LRP6 co-receptor","abstract":"Abstract During the female lifetime, the enlargement of the epithelial compartment dictated by the ovarian cycles is supported by a transient increase in the MaSC population. Notably, activation of Wnt/β-catenin signaling is an important trigger for MaSC expansion. Here, we report that the miR-424/503 cluster is a novel modulator of canonical Wnt-signaling in the mammary epithelium that exerts its function by targeting the LRP6 co-receptor. Additionally, we show that the loss of this microRNA cluster is associated with breast cancers possessing high levels of Wnt/β-catenin signaling.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2021,"id":220725,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9513,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":737389,"name":"Ruth Rodríguez‐Barrueco","orcid":"0000-0003-4925-8865","position":1,"is_corresponding":false},{"id":16315,"name":"Koon‐Kiu Yan","orcid":"0000-0003-2337-485X","position":2,"is_corresponding":false},{"id":820927,"name":"Meredith L. Davis","orcid":null,"position":3,"is_corresponding":false},{"id":738004,"name":"Rachel Werner","orcid":null,"position":4,"is_corresponding":false},{"id":737391,"name":"Laura Devis","orcid":"0000-0003-3736-3983","position":5,"is_corresponding":false},{"id":393082,"name":"Partha Mukhopadhyay","orcid":"0000-0001-5817-0174","position":6,"is_corresponding":false},{"id":55257,"name":"Jiyang Yu","orcid":"0000-0003-1244-4429","position":7,"is_corresponding":false},{"id":737392,"name":"David Llobet‐Navàs","orcid":"0000-0003-1443-7003","position":8,"is_corresponding":false},{"id":562321,"name":"José Silva","orcid":"0000-0001-5487-1117","position":9,"is_corresponding":false},{"id":737388,"name":"Erin A. Nekritz","orcid":"0000-0002-1916-5193","position":0,"is_corresponding":true}],"reference_count":28,"raw_metadata":null,"created_at":"2026-07-18T23:53:50.838581Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}