{"doi":"10.1101/2021.04.28.441769","title":"Striatal and prefrontal D2R and SERT distributions contrastingly correlate with default-mode connectivity","abstract":"Abstract The molecular substrate of resting-state functional connectivity (rs-FC) remains poorly understood. We aimed to elucidate interactions of dopamine D2 receptor (D2R) and serotonin transporter (SERT) availabilities in main dopaminergic and serotonergic projection areas with the default-mode network (DMN) and two other resting-state networks (RSNs), the salience (SN) and sensorimotor networks (SMN). We performed simultaneous PET/fMRI scans in rats using [ 11 C]raclopride and [ 11 C]DASB to image D2R and SERT distributions, showing for the first time direct relationships between rs-FC and molecular properties of the rodent brain. We found negative associations between CPu D2R availability and all RSNs investigated. Strikingly, medial prefrontal SERT correlated both positively with anterior DMN rs-FC and negatively with rs-FC between the other networks, underlining serotonin’s intricate role in this region. By further elucidating the link between molecular brain properties and its network-level function, our data support future diagnostic and therapeutic strategies. Teaser Simultaneous PET/fMRI indicates direct associations between monoaminergic neurotransmission and brain functional networks.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2021,"id":218658,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9507,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":718789,"name":"Mario Amend","orcid":null,"position":1,"is_corresponding":false},{"id":718337,"name":"Rakibul Hafiz","orcid":"0000-0001-6416-0490","position":2,"is_corresponding":false},{"id":28550,"name":"Bharat B. Biswal","orcid":"0000-0002-3710-3500","position":3,"is_corresponding":false},{"id":719352,"name":"Andreas Maurer","orcid":"0000-0003-2412-5361","position":4,"is_corresponding":false},{"id":488398,"name":"Bernd J. Pichler","orcid":"0000-0001-6784-5524","position":5,"is_corresponding":false},{"id":718338,"name":"Hans F. Wehrl","orcid":"0000-0003-4692-3209","position":6,"is_corresponding":false},{"id":718339,"name":"Kristina Herfert","orcid":"0000-0003-0231-7717","position":7,"is_corresponding":false},{"id":718336,"name":"Tudor M. Ionescu","orcid":"0000-0002-7623-9566","position":0,"is_corresponding":true}],"reference_count":75,"raw_metadata":null,"created_at":"2026-07-18T23:53:29.626149Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}