{"doi":"10.1101/2021.04.27.441671","title":"Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization","abstract":"Abstract Soluble adenylyl cyclase (sAC: ADCY10) is essential for activating dormant sperm. Studies of freshly dissected mouse sperm identified sAC as needed for initiating capacitation and activating motility. We now use an improved sAC inhibitor, TDI-10229, for a comprehensive analysis of sAC function in human sperm. Unlike dissected mouse sperm, human sperm are collected post-ejaculation, after sAC activity has already been stimulated. Even in ejaculated human sperm, TDI-10229 interrupts stimulated motility and capacitation, and it prevents acrosome reaction in capacitated sperm. At present, there are no non-hormonal, pharmacological methods for contraception. Because sAC activity is required post-ejaculation at multiple points during the sperm’s journey to fertilize the oocyte, sAC inhibitors define candidates for non-hormonal, on-demand contraceptives suitable for delivery via intravaginal devices in females.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2021,"id":217400,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9553,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":814762,"name":"Lubna Ghanem","orcid":null,"position":1,"is_corresponding":false},{"id":814763,"name":"Thomas Rossetti","orcid":null,"position":2,"is_corresponding":false},{"id":810226,"name":"Navpreet Kaur","orcid":"0000-0002-5900-6066","position":3,"is_corresponding":false},{"id":814764,"name":"Carla Ritagliati","orcid":null,"position":4,"is_corresponding":false},{"id":814254,"name":"Jacob Ferreira","orcid":"0000-0003-2146-9732","position":5,"is_corresponding":false},{"id":583594,"name":"Darío Krapf","orcid":"0000-0001-7607-1954","position":6,"is_corresponding":false},{"id":348622,"name":"Lis C. Puga Molina","orcid":"0000-0001-7937-4918","position":7,"is_corresponding":false},{"id":348625,"name":"Celia M. Santi","orcid":"0000-0002-5101-1303","position":8,"is_corresponding":false},{"id":481285,"name":"Jan N. Hansen","orcid":"0000-0002-0489-7535","position":9,"is_corresponding":false},{"id":481290,"name":"Dagmar Wachten","orcid":"0000-0003-4800-6332","position":10,"is_corresponding":false},{"id":814765,"name":"Makoto Fushimi","orcid":null,"position":11,"is_corresponding":false},{"id":671225,"name":"Peter T. Meinke","orcid":"0000-0002-7548-6215","position":12,"is_corresponding":false},{"id":246034,"name":"Jochen Buck","orcid":"0000-0002-3568-5869","position":13,"is_corresponding":false},{"id":246035,"name":"Lonny R. Levin","orcid":"0000-0002-5204-6356","position":14,"is_corresponding":false},{"id":456905,"name":"Melanie Balbach","orcid":"0000-0002-9752-9888","position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":null,"created_at":"2026-07-18T23:53:20.374789Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}