{"doi":"10.1101/2021.04.02.438254","title":"Focal fMRI signal enhancement with implantable inductively coupled detectors","abstract":"ABSTRACT Despite extensive efforts to increase the signal-to-noise ratio (SNR) of fMRI images for brain-wide mapping, technical advances of focal brain signal enhancement are lacking, in particular, for animal brain imaging. Emerging studies have combined fMRI with fiber optic-based optogenetics to decipher circuit-specific neuromodulation from meso to macroscales. Acquiring fMRI signal with high spatiotemporal resolution is needed to bridge cross-scale functional dynamics, but SNR of targeted cortical regions is a limiting factor. We have developed a multi-modal fMRI imaging platform with an implanted inductive coil detector. This detector boosts the tSNR of MRI images, showing a 2-3 fold sensitivity gain over conventional coil configuration. In contrast to the cryoprobe or array coils with limited spaces for implanted brain interface, this setup offers a unique advantage to study brain circuit connectivity with optogenetic stimulation and can be further extended to other multi-modal fMRI mapping schemes.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2021,"id":218575,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9543,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":816356,"name":"Qi Wang","orcid":"0000-0001-7129-1974","position":1,"is_corresponding":false},{"id":575981,"name":"Sangcheon Choi","orcid":"0000-0001-7327-1344","position":2,"is_corresponding":false},{"id":720434,"name":"Hang Zeng","orcid":"0009-0002-7562-6764","position":3,"is_corresponding":false},{"id":675724,"name":"Kengo Takahashi","orcid":"0000-0002-3532-1512","position":4,"is_corresponding":false},{"id":285359,"name":"Chunqi Qian","orcid":"0000-0003-4528-4572","position":5,"is_corresponding":false},{"id":251801,"name":"Xin Yu","orcid":"0000-0001-9890-5489","position":6,"is_corresponding":false},{"id":816355,"name":"Yi Chen","orcid":"0000-0003-3980-9184","position":0,"is_corresponding":true}],"reference_count":48,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:53:29.626149Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}