{"doi":"10.1101/2021.03.20.21254005","title":"Alternative splicing of <i>OAS1</i> alters the risk for severe COVID-19","abstract":"ABSTRACT A locus containing OAS1/2/3 has been identified as a risk locus for severe COVID-19 among Europeans ancestry individuals, with a protective haplotype of ∼75 kilobases derived from Neanderthals. Here, we show that among several potentially causal variants at this locus, a splice variant of OAS1 occurs in people of African ancestry independently of the Neanderthal haplotype and confers protection against COVID-19 of a magnitude similar to that seen in individuals without African ancestry.","journal":"medRxiv","year":2021,"id":213629,"datarank":0.4335557636844247,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"self_citation_contribution":0.4335557636844247,"citation_network_contribution":0.0,"self_endowment_contribution":0.4335557636844247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.952,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":267234,"name":"Guillaume Butler‐Laporte","orcid":"0000-0001-5388-0396","position":1,"is_corresponding":false},{"id":63302,"name":"Atlas Khan","orcid":"0000-0002-6651-2725","position":2,"is_corresponding":false},{"id":653055,"name":"Theodore G. Drivas","orcid":"0000-0002-8717-0111","position":3,"is_corresponding":false},{"id":24655,"name":"Gina M. Peloso","orcid":"0000-0002-5355-8636","position":4,"is_corresponding":false},{"id":267235,"name":"Tomoko Nakanishi","orcid":"0000-0001-9510-5646","position":5,"is_corresponding":false},{"id":98507,"name":"Anurag Verma","orcid":"0000-0002-5063-9107","position":6,"is_corresponding":false},{"id":58245,"name":"Krzysztof Kiryluk","orcid":"0000-0002-5047-6715","position":7,"is_corresponding":false},{"id":37303,"name":"J. Brent Richards","orcid":"0000-0002-3746-9086","position":8,"is_corresponding":false},{"id":424253,"name":"Hugo Zeberg","orcid":"0000-0001-7118-1249","position":9,"is_corresponding":false},{"id":108708,"name":"Jennifer E. Huffman","orcid":"0000-0002-9672-2491","position":0,"is_corresponding":true}],"reference_count":19,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:52:36.886828Z","pmid":"33791713","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}