{"doi":"10.1101/2021.03.06.434210","title":"Sleep deprivation exacerbates seizures and diminishes GABAergic tonic inhibition","abstract":"Abstract Patients with epilepsy report that sleep deprivation is a common trigger for breakthrough seizures. The basic mechanism of this phenomenon is unknown. In the Kv1.1 -/- mouse model of epilepsy, daily sleep deprivation indeed exacerbated seizures though these effects were lost after the 3 rd day. Sleep deprivation also accelerated mortality in ~52% of Kv1.1 -/- mice, not observed in controls. Voltage-clamp experiments on the day after recovery from sleep deprivation showed reductions in GABAergic tonic inhibition in dentate granule cells both in Kv1.1 -/- and wild-type mice. Our results suggest that sleep deprivation is detrimental to seizures and survival, possibly due to reductions in GABAergic tonic inhibition.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2021,"id":217263,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9597,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":814682,"name":"Yu‐Zhen Pan","orcid":null,"position":1,"is_corresponding":false},{"id":340556,"name":"Eli Wallace","orcid":"0000-0003-2119-1056","position":2,"is_corresponding":false},{"id":340557,"name":"Jesse A. Pfammatter","orcid":"0000-0001-8352-2979","position":3,"is_corresponding":false},{"id":340558,"name":"Mathew V. Jones","orcid":"0000-0003-2714-8411","position":4,"is_corresponding":false},{"id":306968,"name":"Rama Maganti","orcid":"0000-0001-5472-1645","position":5,"is_corresponding":false},{"id":814681,"name":"Sai Surthi Konduru","orcid":null,"position":0,"is_corresponding":true}],"reference_count":22,"raw_metadata":null,"created_at":"2026-07-18T23:53:20.374789Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}