{"doi":"10.1101/2021.03.04.433919","title":"An Essential Role of UBXN3B in B Lymphopoiesis","abstract":"ABSTRACT Hematopoiesis is finely regulated to enable timely production of the right numbers and types of mature immune cells to maintain tissue homeostasis. Dysregulated hematopoiesis may compromise antiviral immunity and/or exacerbate immunopathogenesis. Herein, we report an essential role of UBXN3B in maintenance of hematopoietic homeostasis and restriction of immunopathogenesis during respiratory viral infection. Ubxn3b deficient ( Ubxn3b −/− ) mice are highly vulnerable to SARS-CoV-2 and influenza A infection, characterized by more severe lung immunopathology, lower virus-specific IgG, significantly fewer B cells, but more myeloid cells than Ubxn3b +/+ littermates. This aberrant immune compartmentalization is recapitulated in uninfected Ubxn3b −/− mice. Mechanistically, UBXN3B controls precursor B-I (pre-BI) transition to pre-BII and subsequent proliferation in a cell-intrinsic manner, by maintaining BLNK protein stability and pre-BCR signaling. These results reveal an essential role of UBXN3B for the early stage of B cell development.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2021,"id":226343,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9545,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":341781,"name":"Duomeng Yang","orcid":"0000-0003-2937-7402","position":1,"is_corresponding":false},{"id":341780,"name":"Tao Lin","orcid":"0000-0001-7440-4954","position":2,"is_corresponding":false},{"id":106322,"name":"Andrew G. Harrison","orcid":"0000-0002-0224-8937","position":3,"is_corresponding":false},{"id":297890,"name":"Binsheng Wang","orcid":"0000-0002-1206-5843","position":4,"is_corresponding":false},{"id":455500,"name":"Blake L. Torrance","orcid":"0000-0001-8647-2436","position":5,"is_corresponding":false},{"id":829347,"name":"Kepeng Wang","orcid":"0000-0001-6428-4709","position":6,"is_corresponding":false},{"id":411589,"name":"Yanlin Wang","orcid":"0000-0002-6908-1529","position":7,"is_corresponding":false},{"id":829348,"name":"Long Yang","orcid":"0000-0002-1481-0923","position":8,"is_corresponding":false},{"id":253999,"name":"Laura Haynes","orcid":"0000-0002-5006-3339","position":9,"is_corresponding":false},{"id":497877,"name":"Gong Cheng","orcid":"0000-0001-7447-5488","position":10,"is_corresponding":false},{"id":250005,"name":"Anthony T. Vella","orcid":"0000-0003-4600-5504","position":11,"is_corresponding":false},{"id":245049,"name":"Erol Fikrig","orcid":"0000-0002-5884-6047","position":12,"is_corresponding":false},{"id":106324,"name":"Penghua Wang","orcid":"0000-0002-7332-1871","position":13,"is_corresponding":false},{"id":341779,"name":"Tingting Geng","orcid":"0000-0003-2309-7637","position":0,"is_corresponding":true}],"reference_count":43,"raw_metadata":null,"created_at":"2026-07-18T23:54:34.185847Z","pmid":"34462748","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}