{"doi":"10.1101/2021.03.02.432977","title":"Neutralizing IFNL3 Autoantibodies in Severe COVID-19 Identified Using Molecular Indexing of Proteins by Self-Assembly","abstract":"Unbiased antibody profiling can identify the targets of an immune reaction. A number of likely pathogenic autoreactive antibodies have been associated with life-threatening SARS-CoV-2 infection; yet, many additional autoantibodies likely remain unknown. Here we present Molecular Indexing of Proteins by Self Assembly (MIPSA), a technique that produces ORFeome-scale libraries of proteins covalently coupled to uniquely identifying DNA barcodes for analysis by sequencing. We used MIPSA to profile circulating autoantibodies from 55 patients with severe COVID-19 against 11,076 DNA-barcoded proteins of the human ORFeome library. MIPSA identified previously known autoreactivities, and also detected undescribed neutralizing interferon lambda 3 (IFN-λ3) autoantibodies. At-risk individuals with anti- IFN-λ3 antibodies may benefit from interferon supplementation therapies, such as those currently undergoing clinical evaluation.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2021,"id":214728,"datarank":0.32958368660043297,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.0,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9525,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":528266,"name":"Jonathan Gunn","orcid":"0000-0002-3914-1690","position":1,"is_corresponding":false},{"id":809496,"name":"Puwanat Sangkhapreecha","orcid":null,"position":2,"is_corresponding":false},{"id":108422,"name":"Daniel R. Monaco","orcid":null,"position":3,"is_corresponding":false},{"id":370638,"name":"Xuwen Alice Zheng","orcid":null,"position":4,"is_corresponding":false},{"id":808760,"name":"Hung-Ji Tsai","orcid":"0000-0003-4192-9310","position":5,"is_corresponding":false},{"id":809497,"name":"Azaan Wilbon","orcid":null,"position":6,"is_corresponding":false},{"id":555588,"name":"William R. Morgenlander","orcid":"0000-0001-7205-3732","position":7,"is_corresponding":false},{"id":808761,"name":"Yi Dong","orcid":"0000-0002-9802-4953","position":8,"is_corresponding":false},{"id":808762,"name":"Sahana Jayaraman","orcid":"0000-0003-3413-2530","position":9,"is_corresponding":false},{"id":800855,"name":"Lorenzo Tosi","orcid":"0000-0003-1192-9547","position":10,"is_corresponding":false},{"id":436627,"name":"Biju Parekkadan","orcid":"0000-0002-3408-8085","position":11,"is_corresponding":false},{"id":399734,"name":"Alan N. Baer","orcid":"0000-0001-8344-013X","position":12,"is_corresponding":false},{"id":18050,"name":"Mario Roederer","orcid":"0000-0001-7448-7040","position":13,"is_corresponding":false},{"id":227514,"name":"Evan M. Bloch","orcid":"0000-0001-8181-9517","position":14,"is_corresponding":false},{"id":227515,"name":"Aaron A.R. Tobian","orcid":"0000-0002-0517-3766","position":15,"is_corresponding":false},{"id":760868,"name":"Israel Zyskind","orcid":"0000-0003-3422-9631","position":16,"is_corresponding":false},{"id":267764,"name":"Jonathan I. Silverberg","orcid":"0000-0003-3686-7805","position":17,"is_corresponding":false},{"id":235991,"name":"Avi Z. Rosenberg","orcid":"0000-0003-2356-950X","position":18,"is_corresponding":false},{"id":355240,"name":"Andrea L. Cox","orcid":"0000-0002-9331-2462","position":19,"is_corresponding":false},{"id":166011,"name":"TOM LLOYD","orcid":null,"position":20,"is_corresponding":false},{"id":257669,"name":"Andrew L. Mammen","orcid":"0000-0003-3732-3252","position":21,"is_corresponding":false},{"id":108428,"name":"H. Benjamin Larman","orcid":"0000-0001-7863-196X","position":22,"is_corresponding":false},{"id":809495,"name":"Joel J. Credle","orcid":null,"position":0,"is_corresponding":true}],"reference_count":53,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:52:51.201033Z","pmid":"33688651","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}