{"doi":"10.1101/2021.02.28.433241","title":"PDX1 directs a core developmentally and evolutionarily conserved gene program in the pancreatic islet","abstract":"Summary Pancreatic and duodenal homeobox 1 (PDX1) is crucial for pancreas organogenesis, yet the dynamic changes in PDX1 targets in mouse or human pancreas development have not been examined. We integrated the PDX1 cistrome with cell lineage-specific gene expression in both mouse and human developing pancreas. We identified a core set of developmentally and evolutionarily conserved PDX1 bound genes that reveal the broad multifaceted role of PDX1 in pancreas development. Despite the well-known, dramatic changes in PDX1 function and expression, we showed that PDX1 binding is largely stable from embryonic pancreas to adult islet. This may point towards a dual role of PDX1, activating or repressing the expression of its targets at different ages, dependent on other functionally-congruent or directly-interacting partners. Our work also suggests that PDX1 functions not only in initiating pancreas differentiation, but also as a potential keepsake of the progenitor program in the adult beta cells.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2021,"id":218450,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.95,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":816624,"name":"Jeffrey C. Raum","orcid":null,"position":1,"is_corresponding":false},{"id":349895,"name":"Junil Kim","orcid":"0000-0002-1202-1808","position":2,"is_corresponding":false},{"id":816222,"name":"Reynold Yu","orcid":"0000-0002-8093-254X","position":3,"is_corresponding":false},{"id":705535,"name":"Juxiang Yang","orcid":null,"position":4,"is_corresponding":false},{"id":477031,"name":"Gabriella Rice","orcid":"0000-0002-9539-0173","position":5,"is_corresponding":false},{"id":704627,"name":"Changhong Li","orcid":"0000-0003-0513-1459","position":6,"is_corresponding":false},{"id":191315,"name":"Kyoung Jae Won","orcid":"0000-0002-2924-9630","position":7,"is_corresponding":false},{"id":304326,"name":"Doris A. Stoffers","orcid":"0000-0003-2626-2124","position":8,"is_corresponding":false},{"id":704629,"name":"Diana E. Stanescu","orcid":"0000-0002-2410-8951","position":9,"is_corresponding":false},{"id":502799,"name":"Xiaodun Yang","orcid":"0000-0001-9253-9449","position":0,"is_corresponding":true}],"reference_count":44,"raw_metadata":null,"created_at":"2026-07-18T23:53:29.626149Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}