{"doi":"10.1101/2021.02.25.432905","title":"A public broadly neutralizing antibody class targets a membrane-proximal anchor epitope of influenza virus hemagglutinin","abstract":"Summary Broadly neutralizing antibodies against influenza virus hemagglutinin (HA) have the potential to provide universal protection against influenza virus infections. Here, we report a distinct class of broadly neutralizing antibodies targeting an epitope toward the bottom of the HA stalk domain where HA is “anchored” to the viral membrane. Antibodies targeting this membrane-proximal anchor epitope utilized a highly restricted repertoire, which encode for two conserved motifs responsible for HA binding. Anchor targeting B cells were common in the human memory B cell repertoire across subjects, indicating pre-existing immunity against this epitope. Antibodies against the anchor epitope at both the serological and monoclonal antibody levels were potently induced in humans by a chimeric HA vaccine, a potential universal influenza virus vaccine. Altogether, this study reveals an underappreciated class of broadly neutralizing antibodies against H1-expressing viruses that can be robustly recalled by a candidate universal influenza virus vaccine.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2021,"id":216438,"datarank":0.24141568686511508,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.0,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9497,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":284389,"name":"Julianna Han","orcid":"0000-0002-3402-2609","position":1,"is_corresponding":false},{"id":266564,"name":"Henry A. 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Richey","orcid":"0000-0001-7854-1833","position":11,"is_corresponding":false},{"id":269130,"name":"Micah E. Tepora","orcid":null,"position":12,"is_corresponding":false},{"id":269131,"name":"Dalia J. Bitar","orcid":null,"position":13,"is_corresponding":false},{"id":266563,"name":"Siriruk Changrob","orcid":"0000-0002-1826-4333","position":14,"is_corresponding":false},{"id":104913,"name":"Shirin Strohmeier","orcid":null,"position":15,"is_corresponding":false},{"id":578783,"name":"Min Huang","orcid":"0000-0003-1504-4754","position":16,"is_corresponding":false},{"id":1489,"name":"Adolfo Garcı́a-Sastre","orcid":"0000-0002-6551-1827","position":17,"is_corresponding":false},{"id":123992,"name":"Raffael Nachbagauer","orcid":"0000-0001-5568-5420","position":18,"is_corresponding":false},{"id":234854,"name":"Peter Palese","orcid":"0000-0002-0337-5823","position":19,"is_corresponding":false},{"id":106715,"name":"Jesse D. Bloom","orcid":"0000-0003-1267-3408","position":20,"is_corresponding":false},{"id":103779,"name":"Florian Krammer","orcid":"0000-0003-4121-776X","position":21,"is_corresponding":false},{"id":234853,"name":"Lynda Coughlan","orcid":"0000-0001-9880-6560","position":22,"is_corresponding":false},{"id":230082,"name":"Andrew B. Ward","orcid":"0000-0001-7153-3769","position":23,"is_corresponding":false},{"id":233144,"name":"Patrick C. Wilson","orcid":"0000-0002-3537-1245","position":24,"is_corresponding":false},{"id":266555,"name":"Jenna J. Guthmiller","orcid":"0000-0001-7566-3536","position":0,"is_corresponding":true}],"reference_count":70,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:53:11.245932Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}