{"doi":"10.1101/2021.02.11.430828","title":"Comprehensive phenotypic analysis of the Dp1Tyb mouse strain reveals a broad range of Down Syndrome-related phenotypes","abstract":"Abstract Down syndrome (DS), trisomy 21, results in many complex phenotypes including cognitive deficits, heart defects and craniofacial alterations. Phenotypes arise from an extra copy of human chromosome 21 (Hsa21) genes. However, causative genes remain mostly unknown. Animal models enable identification of these genes and pathological mechanisms. The Dp1Tyb mouse model of DS has an extra copy of 63% of Hsa21-orthologous mouse genes. Here, we comprehensively phenotype Dp1Tyb mice and find wide-ranging DS-like phenotypes including aberrant megakaryopoiesis, reduced bone density, and deficits in memory, locomotion, hearing and sleep. Thus, Dp1Tyb mice are an excellent model for studies of many complex DS phenotypes.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2021,"id":220175,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8949,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":266990,"name":"Heather Cater","orcid":"0000-0002-8696-6070","position":1,"is_corresponding":false},{"id":489424,"name":"Sheona Watson-Scales","orcid":null,"position":2,"is_corresponding":false},{"id":541267,"name":"Simon Greenaway","orcid":null,"position":3,"is_corresponding":false},{"id":819339,"name":"Jennifer Müller","orcid":"0000-0001-6497-4320","position":4,"is_corresponding":false},{"id":819731,"name":"Dorota Gibbins","orcid":null,"position":5,"is_corresponding":false},{"id":819732,"name":"Mihaela Nemes","orcid":null,"position":6,"is_corresponding":false},{"id":819340,"name":"Amy Slender","orcid":"0000-0002-2851-253X","position":7,"is_corresponding":false},{"id":269215,"name":"Tertius Hough","orcid":null,"position":8,"is_corresponding":false},{"id":491231,"name":"Piia Keskivali-Bond","orcid":null,"position":9,"is_corresponding":false},{"id":545602,"name":"Cheryl L. Scudamore","orcid":"0000-0002-7101-1714","position":10,"is_corresponding":false},{"id":241025,"name":"Eleanor Herbert","orcid":"0000-0002-2216-7771","position":11,"is_corresponding":false},{"id":803799,"name":"Gareth Banks","orcid":"0000-0002-8647-667X","position":12,"is_corresponding":false},{"id":819733,"name":"Helene Mobbs","orcid":null,"position":13,"is_corresponding":false},{"id":819341,"name":"Tara Canonica","orcid":"0009-0004-1873-7227","position":14,"is_corresponding":false},{"id":819342,"name":"Justin Tosh","orcid":"0000-0002-1857-995X","position":15,"is_corresponding":false},{"id":819343,"name":"Suzanna Noy","orcid":"0000-0002-9885-7680","position":16,"is_corresponding":false},{"id":819344,"name":"Miriam Llorian","orcid":"0000-0003-2582-6602","position":17,"is_corresponding":false},{"id":819345,"name":"Patrick M. Nolan","orcid":"0000-0001-5550-0334","position":18,"is_corresponding":false},{"id":271654,"name":"Julian L. Griffin","orcid":"0000-0003-1336-7744","position":19,"is_corresponding":false},{"id":819346,"name":"Mark Good","orcid":"0000-0002-1824-1203","position":20,"is_corresponding":false},{"id":86644,"name":"Michelle Simon","orcid":null,"position":21,"is_corresponding":false},{"id":6405,"name":"Ann‐Marie Mallon","orcid":"0000-0003-4047-4019","position":22,"is_corresponding":false},{"id":268820,"name":"Sara Wells","orcid":"0000-0002-0572-0600","position":23,"is_corresponding":false},{"id":238175,"name":"Elizabeth Fisher","orcid":"0000-0003-2850-9936","position":24,"is_corresponding":false},{"id":270081,"name":"Victor L. J. Tybulewicz","orcid":"0000-0003-2439-0798","position":25,"is_corresponding":false},{"id":488249,"name":"Eva Lana‐Elola","orcid":"0000-0003-3351-5820","position":0,"is_corresponding":true}],"reference_count":95,"raw_metadata":null,"created_at":"2026-07-18T23:53:42.928212Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}