{"doi":"10.1101/2021.02.09.430314","title":"Disruption of nuclear architecture as a cause of COVID-19 induced anosmia","abstract":"Olfaction relies on a coordinated partnership between odorant flow and neuronal communication. Disruption in our ability to detect odors, or anosmia, has emerged as a hallmark symptom of infection with SARS-CoV-2, yet the mechanism behind this abrupt sensory deficit remains elusive. Here, using molecular evaluation of human olfactory epithelium (OE) from subjects succumbing to COVID-19 and a hamster model of SARS-CoV-2 infection, we discovered widespread downregulation of olfactory receptors (ORs) as well as key components of their signaling pathway. OR downregulation likely represents a non-cell autonomous effect, since SARS-CoV-2 detection in OSNs is extremely rare both in human and hamster OEs. A likely explanation for the reduction of OR transcription is the striking reorganization of nuclear architecture observed in the OSN lineage, which disrupts multi-chromosomal compartments regulating OR expression in humans and hamsters. Our experiments uncover a novel molecular mechanism by which a virus with a very selective tropism can elicit persistent transcriptional changes in cells that evade it, contributing to the severity of COVID-19.","journal":"Computer Methods in Applied Mechanics and Engineering","year":2021,"id":213291,"datarank":0.4943755299006494,"base_score":3.295836866004329,"endowment":3.295836866004329,"self_citation_contribution":0.4943755299006494,"citation_network_contribution":0.0,"self_endowment_contribution":0.4943755299006494,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":26,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9536,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":452558,"name":"Albana Kodra","orcid":"0000-0003-4267-3679","position":1,"is_corresponding":false},{"id":103711,"name":"Daisy A. Hoagland","orcid":"0000-0002-6781-3079","position":2,"is_corresponding":false},{"id":284413,"name":"John F. Fullard","orcid":"0000-0001-9874-2907","position":3,"is_corresponding":false},{"id":793397,"name":"Hani Shayya","orcid":"0000-0002-0041-1956","position":4,"is_corresponding":false},{"id":292980,"name":"Arina D. Omer","orcid":"0000-0003-1336-2505","position":5,"is_corresponding":false},{"id":252006,"name":"Stuart Firestein","orcid":"0000-0003-1774-5853","position":6,"is_corresponding":false},{"id":302121,"name":"Qizhi Gong","orcid":"0000-0002-7453-6508","position":7,"is_corresponding":false},{"id":107943,"name":"Peter Canoll","orcid":"0000-0002-7001-0226","position":8,"is_corresponding":false},{"id":296382,"name":"James E. Goldman","orcid":"0000-0003-2135-8936","position":9,"is_corresponding":false},{"id":1203,"name":"Panos Roussos","orcid":"0000-0002-4640-6239","position":10,"is_corresponding":false},{"id":103721,"name":"Benjamin R. tenOever","orcid":"0000-0003-0324-3078","position":11,"is_corresponding":false},{"id":238079,"name":"Jonathan B. Overdevest","orcid":"0000-0002-1152-2512","position":12,"is_corresponding":false},{"id":15472,"name":"Stavros Lomvardas","orcid":"0000-0002-7668-3026","position":13,"is_corresponding":false},{"id":805160,"name":"Marianna Zazhytska","orcid":"0000-0002-6874-8272","position":0,"is_corresponding":true}],"reference_count":42,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:52:36.886828Z","pmid":"33594368","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}