{"doi":"10.1101/2021.02.09.429966","title":"Human monoclonal antibodies against <i>Staphylococcus aureus</i> surface antigens recognize <i>in vitro</i> biofilm and <i>in vivo</i> implant infections","abstract":"Abstract Implant-associated Staphylococcus aureus infections are difficult to treat because of biofilm formation. Bacteria in a biofilm are often insensitive to antibiotics and host immunity. Monoclonal antibodies (mAbs) could provide an alternative approach to improve the diagnosis and/or treatment of biofilm-related infections. Here we show that mAbs targeting common surface components of S. aureus can recognize clinically relevant biofilm types. We identify two groups of antibodies: one group that uniquely binds S. aureus in biofilm state and one that recognizes S. aureus in both biofilm and planktonic state. In a mouse model, we show that mAb 4497 (recognizing wall teichoic acid (WTA)) specifically localizes to biofilm-infected implants. In conclusion, we demonstrate the capacity of several human mAbs to detect S. aureus biofilms in vitro and in vivo . This is an important first step to develop mAbs for imaging or treating S. aureus biofilms.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2021,"id":216371,"datarank":0.33873220858903136,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.09731652172391628,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.09731652172391628,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":4,"citers_with_citation_signal":4,"citers_with_endowment":4,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9611,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":684274,"name":"Bruce van Dijk","orcid":null,"position":1,"is_corresponding":false},{"id":812270,"name":"Kok P. M. van Kessel","orcid":"0000-0003-1268-5484","position":2,"is_corresponding":false},{"id":249750,"name":"J.S. Kavanaugh","orcid":"0000-0002-3876-4001","position":3,"is_corresponding":false},{"id":812271,"name":"Carla J. C. de Haas","orcid":"0000-0002-2059-4526","position":4,"is_corresponding":false},{"id":812782,"name":"Piet C. Aerts","orcid":null,"position":5,"is_corresponding":false},{"id":812783,"name":"Marco C. Viveen","orcid":null,"position":6,"is_corresponding":false},{"id":683744,"name":"Edwin C Boel","orcid":"0000-0002-8506-0357","position":7,"is_corresponding":false},{"id":812272,"name":"Ad C. Fluit","orcid":"0000-0003-3432-0021","position":8,"is_corresponding":false},{"id":230750,"name":"Jakub Kwieciński","orcid":"0000-0001-9472-2896","position":9,"is_corresponding":false},{"id":812273,"name":"Gerard C. Krijger","orcid":"0000-0002-5533-8565","position":10,"is_corresponding":false},{"id":812784,"name":"Ruud M. Ramakers","orcid":null,"position":11,"is_corresponding":false},{"id":812785,"name":"Freek J. Beekman","orcid":null,"position":12,"is_corresponding":false},{"id":368608,"name":"Ekaterina Dadachova","orcid":"0000-0001-7300-6479","position":13,"is_corresponding":false},{"id":291603,"name":"Marnix G. E. H. Lam","orcid":"0000-0002-4902-9790","position":14,"is_corresponding":false},{"id":812274,"name":"H. Charles Vogely","orcid":"0000-0002-0934-2985","position":15,"is_corresponding":false},{"id":812275,"name":"Bart C. H. van der Wal","orcid":"0000-0002-2554-4675","position":16,"is_corresponding":false},{"id":567263,"name":"Jos A. G. van Strijp","orcid":"0000-0001-6253-0830","position":17,"is_corresponding":false},{"id":230751,"name":"Alexander R. Horswill","orcid":"0000-0002-5568-0096","position":18,"is_corresponding":false},{"id":331496,"name":"Harrie Weinans","orcid":"0000-0002-2275-6170","position":19,"is_corresponding":false},{"id":683745,"name":"Suzan HM Rooijakkers","orcid":"0000-0003-4102-0377","position":20,"is_corresponding":false},{"id":683743,"name":"Lisanne de Vor","orcid":"0000-0002-2289-3378","position":0,"is_corresponding":true}],"reference_count":85,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:53:11.245932Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}