{"doi":"10.1101/2021.02.01.429208","title":"Neuronal control of maternal provisioning in response to social cues","abstract":"ABSTRACT Mothers contribute cytoplasmic components to their progeny in a process called maternal provisioning. Provisioning is influenced by the parental environment, but the molecular pathways that transmit environmental cues from mother to progeny are not well understood. Here we show that in C. elegans , social cues modulate maternal provisioning to regulate gene silencing in offspring. Intergenerational signal transmission depends on a pheromone-sensing neuron and neuronal FMRF (Phe-Met-Arg-Phe)-like peptides. Parental FMRF signaling promotes the deposition of mRNAs for translational components in progeny, which in turn reduces gene silencing. Previous studies had implicated FMRF signaling in short-term responses such as modulated feeding behavior in response to the metabolic state 1,2 , but our data reveal a broader role, to coordinate energetically expensive processes such as translation and maternal provisioning. This study identifies a new pathway for intergenerational communication, distinct from previously discovered pathways involving small RNAs and chromatin, that links sensory perception to maternal provisioning.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2021,"id":220161,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9494,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":793700,"name":"Gareth Harris","orcid":null,"position":1,"is_corresponding":false},{"id":793701,"name":"Sabine Keppler‐Ross","orcid":null,"position":2,"is_corresponding":false},{"id":793300,"name":"Trisha Brock","orcid":"0000-0003-4540-0123","position":3,"is_corresponding":false},{"id":392959,"name":"Abdul Rouf","orcid":"0000-0001-9945-1933","position":4,"is_corresponding":false},{"id":392960,"name":"Rebecca A. Butcher","orcid":"0000-0002-0925-4459","position":5,"is_corresponding":false},{"id":295481,"name":"Sylvia E. J. Fischer","orcid":"0000-0003-4290-0093","position":6,"is_corresponding":false},{"id":297564,"name":"Konstantinos Kagias","orcid":"0000-0003-0691-2898","position":7,"is_corresponding":false},{"id":79205,"name":"Jon Clardy","orcid":"0000-0003-0213-8356","position":8,"is_corresponding":false},{"id":297565,"name":"Yun Zhang","orcid":"0000-0002-7631-858X","position":9,"is_corresponding":false},{"id":11819,"name":"Susan E. Mango","orcid":"0000-0002-2146-3237","position":10,"is_corresponding":false},{"id":793299,"name":"Jadiel A. Wasson","orcid":"0000-0002-2590-7835","position":0,"is_corresponding":true}],"reference_count":82,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:53:42.928212Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}