{"doi":"10.1101/2021.01.31.429012","title":"Disrupted Surfaces of Porous Membranes Reduce Nuclear YAP Localization and Enhance Adipogenesis through Morphological Changes","abstract":"ABSTRACT The disrupted surface of porous membranes, commonly used in tissue-chip and cellular co-culture systems, is known to weaken cell-substrate interactions. Here, we investigated whether disrupted surfaces of membranes with micron and sub-micron scale pores affect YAP localization and differentiation of adipose-derived stem cells (ADSCs). We found that these substrates reduce YAP nuclear localization through decreased cell spreading, consistent with reduced cell-substrate interactions, and in turn enhance adipogenesis, while decreasing osteogenesis. Abstract Figure","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2021,"id":220153,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9573,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":819312,"name":"Stephanie M. Casillo","orcid":"0000-0002-6154-5050","position":1,"is_corresponding":false},{"id":819718,"name":"Spencer J. Perry","orcid":null,"position":2,"is_corresponding":false},{"id":293038,"name":"Ana P. Peredo","orcid":"0000-0001-8383-039X","position":3,"is_corresponding":false},{"id":407418,"name":"Shayan Gholizadeh","orcid":"0000-0001-5534-460X","position":4,"is_corresponding":false},{"id":260337,"name":"Thomas R. Gaborski","orcid":"0000-0002-3676-3208","position":5,"is_corresponding":false},{"id":407419,"name":"Zahra Allahyari","orcid":"0000-0002-8274-9538","position":0,"is_corresponding":true}],"reference_count":55,"raw_metadata":null,"created_at":"2026-07-18T23:53:42.928212Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}