{"doi":"10.1101/2021.01.30.428937","title":"Surviving hypothermia by ferritin-mediated iron detoxification","abstract":"SUMMARY How animals rewire cellular programs to survive cold is a fascinating problem with potential biomedical implications, ranging from emergency medicine to space travel. Studying a hibernation-like response in the free-living nematode Caenorhabditis elegans , we uncovered a regulatory axis that enhances the natural resistance of nematodes to severe cold. This axis involves conserved transcription factors, DAF-16/FoxO and PQM-1, which jointly promote cold survival by upregulating FTN-1, a protein related to mammalian Fth1/ferritin. Moreover, we show that inducing expression of Fth1 also promotes cold survival of mammalian neurons, a cell type particularly sensitive to deterioration in hypothermia. Our findings in both animals and cells suggest that FTN-1/Fth1 facilitates cold survival by detoxifying ROS-generating iron species. We finally show that mimicking the effects of FTN-1/Fth1 with drugs protects neurons from cold-induced degeneration, opening a potential avenue to improved treatments of hypothermia.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2021,"id":220197,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9528,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":819361,"name":"Jarosław Lewandowski","orcid":"0000-0002-8159-8053","position":1,"is_corresponding":false},{"id":819362,"name":"Alicja A. Komur","orcid":"0000-0003-2564-688X","position":2,"is_corresponding":false},{"id":819363,"name":"Daria Sobańska","orcid":"0000-0003-1773-6690","position":3,"is_corresponding":false},{"id":772769,"name":"Yanwu Guo","orcid":"0000-0002-2368-4375","position":4,"is_corresponding":false},{"id":819364,"name":"Karolina Świtońska-Kurkowska","orcid":"0000-0001-6275-7904","position":5,"is_corresponding":false},{"id":819365,"name":"Marcin Frankowski","orcid":"0000-0001-6315-3758","position":6,"is_corresponding":false},{"id":819366,"name":"Maciej Figiel","orcid":"0000-0003-3961-4635","position":7,"is_corresponding":false},{"id":652945,"name":"Rafal Ciosk","orcid":"0000-0003-2234-6216","position":8,"is_corresponding":false},{"id":652943,"name":"Tina Pekeč","orcid":"0000-0002-4222-3312","position":0,"is_corresponding":true}],"reference_count":81,"raw_metadata":null,"created_at":"2026-07-18T23:53:42.928212Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}