{"doi":"10.1101/2021.01.27.428441","title":"Maternal transfer of neutralizing antibodies to OspA after oral vaccination of the rodent reservoir","abstract":"Abstract Lyme Disease presents unique challenges for public health efforts. We hypothesized that transfer of protective antibodies between mothers and offspring should occur after oral vaccination of C3H-HeN mice with E. coli overexpressing OspA. We present new evidence for maternal transfer of vaccine induced neutralizing anti-OspA IgG antibodies to mouse pups through ingestion of colostrum. Protective levels of OspA antibodies in pups were present from 2-5 weeks after birth and they persisted in some mice until 9 weeks of age. This was corroborated by detection of neutralizing antibodies in the serum of all pups at 2-3 weeks after birth and in some mice at 9 weeks of age. A clear association was found between robust antibody responses in mothers and the length of antibody persistence in the respective pups using a novel longitudinal Bayesian model. These factors are likely to impact the enzootic cycle of B. burgdorferi when reservoir targeted OspA-based vaccination interventions are implemented.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2021,"id":222920,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9567,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":487281,"name":"Nisha Nair","orcid":"0000-0001-6605-5555","position":1,"is_corresponding":false},{"id":651715,"name":"Kamalika Samanta","orcid":"0000-0001-6456-601X","position":2,"is_corresponding":false},{"id":739446,"name":"José F. Azevedo","orcid":null,"position":3,"is_corresponding":false},{"id":378266,"name":"Grant Brown","orcid":"0000-0002-7247-7313","position":4,"is_corresponding":false},{"id":284596,"name":"Christine A. Petersen","orcid":"0000-0002-7285-4254","position":5,"is_corresponding":false},{"id":487284,"name":"Maria Gomes‐Solecki","orcid":"0000-0002-3715-4543","position":6,"is_corresponding":false},{"id":824137,"name":"Kathryn A. O’Connell","orcid":"0000-0001-9896-9095","position":0,"is_corresponding":true}],"reference_count":25,"raw_metadata":null,"created_at":"2026-07-18T23:54:07.287704Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}