{"doi":"10.1101/2021.01.22.427567","title":"Bispecific antibody neutralizes circulating SARS-CoV-2 variants, prevents escape and protects mice from disease","abstract":"Summary Neutralizing antibodies targeting the receptor binding domain (RBD) of the SARS-CoV-2 Spike (S) are among the most promising approaches against coronavirus disease 2019 (COVID-19) 1,2 . We developed a bispecific, IgG1-like molecule (CoV-X2) based on two antibodies derived from COVID-19 convalescent donors, C121 and C135 3 . CoV-X2 simultaneously binds two independent sites on the RBD and, unlike its parental antibodies, prevents detectable S binding to Angiotensin-Converting Enzyme 2 (ACE2), the virus cellular receptor. Furthermore, CoV-X2 neutralizes SARS-CoV-2 and its variants of concern, as well as the escape mutants generated by the parental monoclonals. In a novel animal model of SARS-CoV-2 infection with lung inflammation, CoV-X2 protects mice from disease and suppresses viral escape. Thus, simultaneous targeting of non-overlapping RBD epitopes by IgG-like bispecific antibodies is feasible and effective, combining into a single molecule the advantages of antibody cocktails.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2021,"id":216342,"datarank":0.24141568686511508,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.0,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.96,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":525195,"name":"Mattia Pedotti","orcid":"0000-0003-1370-9505","position":1,"is_corresponding":false},{"id":525194,"name":"Luca Simonelli","orcid":"0000-0001-6331-7716","position":2,"is_corresponding":false},{"id":628139,"name":"Petr Nickl","orcid":"0000-0002-4289-0502","position":3,"is_corresponding":false},{"id":16973,"name":"Frauke Muecksch","orcid":"0000-0002-0132-5101","position":4,"is_corresponding":false},{"id":628140,"name":"Irene Cassaniti","orcid":"0000-0002-3385-2088","position":5,"is_corresponding":false},{"id":628141,"name":"Elena Percivalle","orcid":"0000-0002-3355-1410","position":6,"is_corresponding":false},{"id":104705,"name":"Julio C. 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