{"doi":"10.1101/2021.01.12.426433","title":"Acute inflammation, mediated by lung neutrophils, confers enhanced protection against <i>Mycobacterium tuberculosis</i> infection in mice","abstract":"Abstract Inflammation plays a crucial role in the control of Mycobacterium tuberculosis ( M . tb ) infection. In this study, we demonstrate that an inflammatory pulmonary environment at the time of infection mediated by liposaccharide (LPS) treatment in mice confers enhanced protection against M . tb for up to 6 months post infection. This transient protective inflammatory environment was associated with a neutrophil and monocyte/macrophage influx as well as increased inflammatory cytokines. In vitro infection of neutrophils from LPS treated mice demonstrated that LPS neutrophils exhibited increased recognition of M . tb , and had a greater innate capacity for killing M . tb . Finally, partial depletion of neutrophils in LPS treated mice showed an increase in M . tb burden, suggesting neutrophils conferred the enhanced protection observed in LPS treated mice. These results indicate a positive role of an inflammatory environment during initial M . tb infection, and suggests that acute inflammation at the time of M . tb infection can positively alter disease outcome.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2021,"id":222850,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9573,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":245271,"name":"Julia M. Scordo","orcid":"0000-0001-6571-6454","position":1,"is_corresponding":false},{"id":777444,"name":"Paula A. Pino","orcid":"0000-0001-8626-926X","position":2,"is_corresponding":false},{"id":245288,"name":"Jordi B. Torrelles","orcid":"0000-0001-7702-5941","position":3,"is_corresponding":false},{"id":245287,"name":"Joanne Turner","orcid":"0000-0002-0840-7484","position":4,"is_corresponding":false},{"id":588007,"name":"Tucker J. Piergallini","orcid":"0000-0002-3449-071X","position":0,"is_corresponding":true}],"reference_count":67,"raw_metadata":null,"created_at":"2026-07-18T23:54:07.287704Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}