{"doi":"10.1101/2021.01.12.21249672","title":"Characteristics and outcomes of 118,155 COVID-19 individuals with a history of cancer in the United States and Spain","abstract":"Abstract Purpose We aimed to describe the demographics, cancer subtypes, comorbidities and outcomes of patients with a history of cancer with COVID-19 from March to June 2020. Secondly, we compared patients hospitalized with COVID-19 to patients diagnosed with COVID-19 and patients hospitalized with influenza. Methods We conducted a cohort study using eight routinely-collected healthcare databases from Spain and the US, standardized to the Observational Medical Outcome Partnership common data model. Three cohorts of patients with a history of cancer were included: i) diagnosed with COVID-19, ii) hospitalized with COVID-19, and iii) hospitalized with influenza in 2017-2018. Patients were followed from index date to 30 days or death. We reported demographics, cancer subtypes, comorbidities, and 30-day outcomes. Results We included 118,155 patients with a cancer history in the COVID-19 diagnosed and 41,939 in the COVID-19 hospitalized cohorts. The most frequent cancer subtypes were prostate and breast cancer (range: 5-19% and 1-14% in the diagnosed cohort, respectively). Hematological malignancies were also frequent, with non-Hodgkin’s lymphoma being among the 5 most common cancer subtypes in the diagnosed cohort. Overall, patients were more frequently aged above 65 years and had multiple comorbidities. Occurrence of death ranged from 8% to 14% and from 18% to 26% in the diagnosed and h ospitalized COVID-19 cohorts, respectively. Patients hospitalized with influenza (n=242,960) had a similar distribution of cancer subtypes, sex, age and comorbidities but lower occurrence of adverse events. Conclusion Patients with a history of cancer and COVID-19 have advanced age, multiple comorbidities, and a high occurence of COVID-19-related events. Additionaly, hematological malignancies were frequent in these patients.This observational study provides epidemiologic characteristics that can inform clinical care and future etiological studies.","journal":"medRxiv","year":2021,"id":222886,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":0.0,"corpus_rank":10111,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.732,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":32071,"name":"Andrea Pistillo","orcid":"0000-0002-4467-0220","position":1,"is_corresponding":false},{"id":552599,"name":"Martina Recalde","orcid":"0000-0003-2256-618X","position":2,"is_corresponding":false},{"id":32056,"name":"Anthony G. 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Alshammari","orcid":"0000-0002-5630-2468","position":10,"is_corresponding":false},{"id":266938,"name":"Carlos Areia","orcid":"0000-0002-4668-7069","position":11,"is_corresponding":false},{"id":32052,"name":"Clair Blacketer","orcid":"0000-0003-2570-2124","position":12,"is_corresponding":false},{"id":824102,"name":"William Carter","orcid":"0000-0002-1938-4628","position":13,"is_corresponding":false},{"id":258092,"name":"Paula Casajust","orcid":"0000-0003-2733-5436","position":14,"is_corresponding":false},{"id":31867,"name":"Aedín C. Culhane","orcid":"0000-0002-1395-9734","position":15,"is_corresponding":false},{"id":562096,"name":"Dalia Dawoud","orcid":"0000-0002-2105-1937","position":16,"is_corresponding":false},{"id":277987,"name":"Frank DeFalco","orcid":"0000-0002-5810-8298","position":17,"is_corresponding":false},{"id":11351,"name":"Scott L. 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