{"doi":"10.1101/2021.01.11.426209","title":"COVID-19 Severity Is Associated with Differential Antibody Fc-mediated Innate Immune Functions","abstract":"ABSTRACT Beyond neutralization, antibodies elicit several innate immune functions including complement deposition (ADCD), phagocytosis (ADCP), and cytotoxicity (ADCC). These functions can be both beneficial (by clearing pathogens) and/or detrimental (by inducing inflammation). We tested the possibility that qualitative differences in SARS-CoV-2 specific antibody-mediated innate immune functions contribute to Coronavirus disease 2019 (COVID-19) severity. We found that antibodies from hospitalized COVID-19 patients elicited higher ADCD but lower ADCP compared to antibodies from non-hospitalized COVID-19 patients. Consistently, higher ADCD was associated with higher systemic inflammation during COVID-19. Our study points to qualitative, differential features of anti-SARS-CoV-2 antibodies as potential contributors to COVID-19 severity.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2021,"id":213931,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9541,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":331445,"name":"Leila B. Giron","orcid":"0000-0002-3898-5680","position":1,"is_corresponding":false},{"id":551653,"name":"Netanel Zilberstein","orcid":"0000-0001-5409-8654","position":2,"is_corresponding":false},{"id":332950,"name":"Maliha Shaikh","orcid":null,"position":3,"is_corresponding":false},{"id":551652,"name":"R.A. Balk","orcid":"0000-0001-5757-2649","position":4,"is_corresponding":false},{"id":645738,"name":"James N. Moy","orcid":null,"position":5,"is_corresponding":false},{"id":551651,"name":"Christopher B. Forsyth","orcid":"0000-0003-4690-7751","position":6,"is_corresponding":false},{"id":331446,"name":"Ali Keshavarzian","orcid":"0000-0002-7969-3369","position":7,"is_corresponding":false},{"id":328573,"name":"Alan Landay","orcid":"0000-0001-9645-1356","position":8,"is_corresponding":false},{"id":263022,"name":"Mohamed Abdel‐Mohsen","orcid":"0000-0002-9945-4314","position":9,"is_corresponding":false},{"id":501855,"name":"Opeyemi S. Adeniji","orcid":null,"position":0,"is_corresponding":true}],"reference_count":16,"raw_metadata":null,"created_at":"2026-07-18T23:52:41.672172Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}