{"doi":"10.1101/2021.01.11.425291","title":"Restored TDCA and Valine Levels Imitate the Effects of Bariatric Surgery","abstract":"Abstract Obesity is widespread and linked to various co-morbidities. Bariatric surgery has been identified as the only effective treatment, promoting sustained weight loss and the remission of co-morbidities. We performed sleeve-gastrectomies (SGx) in a pre-clinical mouse model of diet-induced obesity (DIO), delineating the effects on long-term remission from obesity. SGx resulted in sustained weight loss and improved glucose tolerance. Mass-spectrometric metabolomic profiling revealed significantly reduced systemic levels of taurodeoxycholic acid (TDCA) and L-valine in DIO mice. Notably, TDCA and L-Valine levels were restored after SGx in both human and mice to levels comparable with lean controls. Strikingly, combined systemic treatment with TDCA and valine induced a profound weight loss in DIO mice analogous to effects observed after SGx. Utilizing indirect calorimetry, we confirmed reduced food intake as causal for TDCA/valine-mediated weight loss via a central inhibition of the melanin-concentrating hormone. In summary, we identified restored TDCA/valine levels as an underlying mechanism of SGx-derived effects on weight loss. Of translational relevance, TDCA and L-valine are presented as novel agents promoting weight loss while reversing obesity-associated metabolic disorders.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2021,"id":218288,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9493,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":246830,"name":"Jasper Iske","orcid":"0000-0001-8647-3092","position":1,"is_corresponding":false},{"id":246831,"name":"Timm Heinbokel","orcid":"0000-0002-3595-0562","position":2,"is_corresponding":false},{"id":566766,"name":"Bhavna N. Desai","orcid":null,"position":3,"is_corresponding":false},{"id":749513,"name":"Héctor Rodríguez Cetina Biefer","orcid":"0000-0002-5855-8993","position":4,"is_corresponding":false},{"id":248612,"name":"Yeqi Nian","orcid":null,"position":5,"is_corresponding":false},{"id":513833,"name":"Felix Krenzien","orcid":"0000-0003-0593-9917","position":6,"is_corresponding":false},{"id":45298,"name":"Hirofumi Uehara","orcid":"0000-0001-5811-5941","position":7,"is_corresponding":false},{"id":246832,"name":"Ryoichi Maenosono","orcid":"0000-0002-9045-5484","position":8,"is_corresponding":false},{"id":246835,"name":"Haruhito Azuma","orcid":"0000-0001-5497-1679","position":9,"is_corresponding":false},{"id":513834,"name":"Johann Pratschke","orcid":"0000-0001-9839-1369","position":10,"is_corresponding":false},{"id":12175,"name":"Christine S. Falk","orcid":"0000-0003-1376-7318","position":11,"is_corresponding":false},{"id":724765,"name":"Tammy Lo","orcid":"0000-0002-0464-5629","position":12,"is_corresponding":false},{"id":569199,"name":"Eric G. Sheu","orcid":"0000-0003-2707-1768","position":13,"is_corresponding":false},{"id":456194,"name":"Ali Tavakkoli","orcid":"0000-0002-7430-1848","position":14,"is_corresponding":false},{"id":424039,"name":"David L. Perkins","orcid":"0000-0002-0164-6036","position":15,"is_corresponding":false},{"id":92114,"name":"Maria‐Luisa Alegre","orcid":"0000-0001-5707-6194","position":16,"is_corresponding":false},{"id":23889,"name":"Alexander S. Banks","orcid":"0000-0003-1787-6925","position":17,"is_corresponding":false},{"id":246837,"name":"Abdallah Elkhal","orcid":"0000-0002-4160-9416","position":18,"is_corresponding":false},{"id":246838,"name":"Stefan G. Tullius","orcid":"0000-0003-3058-3166","position":19,"is_corresponding":false},{"id":246834,"name":"Markus Quante","orcid":"0000-0002-2206-107X","position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:53:29.626149Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}