{"doi":"10.1101/2021.01.10.21249545","title":"Association of Chronic Acid Suppression and Social Determinants of Health with COVID-19 Infection","abstract":"Acid suppressants are a widely-used class of medications previously linked to an increased risk of aerodigestive infections. However, prior studies of these medications as potentially reversible risk factors for COVID-19 have been conflicting. We performed a case-control study involving clinician-abstracted data from 900 health records across 3 US medical centers. We incorporated sociobehavioral predictors of infectious exposure using geomapping to publicly-available data. We found no evidence for an association between chronic acid suppression and incident COVID-19 (adjusted odds ratio 1.04, 95% CI: 0.92-1.17, P =0.515). However, we identified several medical and social features as positive (Latinx ethnicity, BMI ≥ 30, dementia, public transportation use, month of the pandemic) and negative (female sex, concurrent solid tumor, alcohol use disorder) predictors of new-onset infection. These results place both medical and social factors on the same scale within the context of the COVID-19 pandemic, and underscore the importance of comprehensive models of disease.","journal":"medRxiv","year":2021,"id":2254,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0456,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-11","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":27725,"name":"Anna L. Silverman","orcid":"0000-0002-1139-0900","position":1,"is_corresponding":false},{"id":27726,"name":"Saroja Bangaru","orcid":null,"position":2,"is_corresponding":false},{"id":696,"name":"Douglas V. Arneson","orcid":"0000-0002-9464-2586","position":3,"is_corresponding":false},{"id":27727,"name":"Sonya Dasharathy","orcid":"0000-0001-8131-739X","position":4,"is_corresponding":false},{"id":27728,"name":"Nghia Nguyen","orcid":"0000-0002-4043-0430","position":5,"is_corresponding":false},{"id":27729,"name":"Diane Rodden","orcid":null,"position":6,"is_corresponding":false},{"id":27730,"name":"Jonathan Shih","orcid":"0000-0002-8651-7806","position":7,"is_corresponding":false},{"id":51,"name":"Atul Janardhan Butte","orcid":"0000-0002-7433-2740","position":8,"is_corresponding":false},{"id":27732,"name":"Brigid S. Boland","orcid":"0000-0002-5360-8816","position":10,"is_corresponding":false},{"id":700,"name":"Vivek Ashok Rudrapatna","orcid":"0000-0003-1789-3004","position":11,"is_corresponding":false},{"id":27733,"name":"Wael N. El‐Nachef","orcid":"0000-0002-2892-9394","position":12,"is_corresponding":false},{"id":7638,"name":"Bing Zhang","orcid":"0000-0001-8676-2425","position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}