{"doi":"10.1101/2021.01.05.425466","title":"The skin environment controls local dendritic cell differentiation and function through innate IL-13","abstract":"ABSTRACT The signals driving the adaptation of type-2 dendritic cells (DC2s) to diverse peripheral environments are not well understood. We show that the development of CD11b low migratory DC2s, a DC2 population unique to the dermis, requires STAT6- and KLF4-dependent IL-13 signaling, whereas DC2s in lung and small intestine are STAT6-independent. Dermal IL-13 is mostly derived from innate lymphoid cells expressing a resting ICOS+ KLRG1-ST2-phenotype. Analysis of public datasets indicates that human skin DC2s also express an IL-4/IL-13 gene signature compared to blood or spleen, suggesting a similar developmental pathway in mice and humans. In the absence of IL-13 signaling, dermal DC2s are stable in number but remain CD11b hi and show defective activation in response to allergen with diminished ability to support IL-4+ GATA3+ Th development, whereas anti-fungal IL-17+ ROR γ t+ responses are increased. Thus, steady-state IL-13 fosters a non-inflammatory and pro-allergic environment in healthy skin via conditioning of local DC2s.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2021,"id":220053,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9594,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":819240,"name":"Olivier Lamiable","orcid":"0000-0001-7571-9253","position":1,"is_corresponding":false},{"id":486816,"name":"Kerry L. Hilligan","orcid":"0000-0003-1238-1552","position":2,"is_corresponding":false},{"id":819241,"name":"Jodie Chandler","orcid":"0000-0003-2003-573X","position":3,"is_corresponding":false},{"id":613884,"name":"Samuel I. Old","orcid":"0000-0003-1245-4459","position":4,"is_corresponding":false},{"id":314122,"name":"David Eccles","orcid":"0000-0003-4634-4995","position":5,"is_corresponding":false},{"id":486821,"name":"Jianping Yang","orcid":"0000-0001-5336-6530","position":6,"is_corresponding":false},{"id":819242,"name":"Greta R. Webb","orcid":"0000-0003-0348-3119","position":7,"is_corresponding":false},{"id":819243,"name":"Rita G. Domingues","orcid":"0000-0001-8571-1132","position":8,"is_corresponding":false},{"id":819244,"name":"Luis Munoz‐Erazo","orcid":"0000-0003-4202-1515","position":9,"is_corresponding":false},{"id":486822,"name":"Kirsty A. Wakelin","orcid":"0000-0002-2819-0315","position":10,"is_corresponding":false},{"id":486818,"name":"Evelyn Hyde","orcid":"0000-0002-3701-5391","position":11,"is_corresponding":false},{"id":486817,"name":"Shiau‐Choot Tang","orcid":"0000-0002-0427-6333","position":12,"is_corresponding":false},{"id":614055,"name":"Sally C. Chappell","orcid":null,"position":13,"is_corresponding":false},{"id":819245,"name":"Charles R. Mackay","orcid":"0000-0002-6338-7340","position":14,"is_corresponding":false},{"id":77614,"name":"Frank Brombacher","orcid":"0000-0001-8881-6781","position":15,"is_corresponding":false},{"id":330710,"name":"Alan Sher","orcid":"0000-0001-7053-2895","position":16,"is_corresponding":false},{"id":445304,"name":"Roxane Tussiwand","orcid":"0000-0002-1712-868X","position":17,"is_corresponding":false},{"id":486824,"name":"Lisa M. Connor","orcid":"0000-0002-3882-8765","position":18,"is_corresponding":false},{"id":313436,"name":"Dragana Janković","orcid":"0000-0001-7360-1809","position":19,"is_corresponding":false},{"id":607043,"name":"Matthew R. Hepworth","orcid":"0000-0002-9613-7858","position":20,"is_corresponding":false},{"id":613886,"name":"Graham Le Gros","orcid":"0000-0002-5721-0442","position":21,"is_corresponding":false},{"id":486825,"name":"Franca Ronchese","orcid":"0000-0001-5835-8230","position":22,"is_corresponding":false},{"id":486820,"name":"Johannes U. Mayer","orcid":"0000-0001-6225-7803","position":0,"is_corresponding":true}],"reference_count":99,"raw_metadata":null,"created_at":"2026-07-18T23:53:42.928212Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}