{"doi":"10.1101/2020.12.30.424888","title":"Orchestrated Excitatory and Inhibitory Learning Rules Lead to the Unsupervised Emergence of Self-sustained and Inhibition-stabilized Dynamics","abstract":"ABSTRACT Self-sustaining neural activity maintained through local recurrent connections is of fundamental importance to cortical function. We show that Up-states—an example of self-sustained, inhibition-stabilized network dynamics—emerge in cortical circuits across three weeks of ex vivo development, establishing the presence of unsupervised learning rules capable of generating self-sustained dynamics. Previous computational models have established that four sets of weights ( W E ← E , W E ← I , W I ← E , W I ← I ) must interact in an orchestrated manner to produce Up-states, but have not addressed how a family of learning rules can operate in parallel at all four weight classes to generate self-sustained inhibition-stabilized dynamics. Using numerical and analytical methods we show that, in part due to the paradoxical effect, standard homeostatic rules are only stable in a narrow parameter regime. In contrast, we show that a family of biologically plausible learning rules based on “cross-homeostatic” plasticity robustly lead to the emergence of self-sustained, inhibition-stabilized dynamics.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2021,"id":222900,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9405,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":824115,"name":"Rodrigo Laje","orcid":"0000-0003-1481-303X","position":1,"is_corresponding":false},{"id":308123,"name":"Dean V. Buonomano","orcid":"0000-0002-8528-9231","position":2,"is_corresponding":false},{"id":824114,"name":"Saray Soldado-Magraner","orcid":"0000-0003-4890-2671","position":0,"is_corresponding":true}],"reference_count":83,"raw_metadata":null,"created_at":"2026-07-18T23:54:07.287704Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}