{"doi":"10.1101/2020.12.30.424747","title":"<i>De novo</i> germline mutation in the Dual Specificity Phosphatase 10 gene accelerates autoimmune diabetes in Non-Obese Diabetic (NOD) mice","abstract":"Abstract Here we report the isolation by selective breeding of two sublines of Non-Obese Diabetic (NOD) mice exhibiting a significant difference in the incidence of autoimmune type 1 diabetes (T1D). Whole genome sequencing of the NOD/Nck H (high T1D incidence) and NOD/Nck L (low T1D incidence) revealed the presence of a limited number of variants specific to each subline. Treating the age of T1D onset as a quantitative trait and using automated meiotic mapping (AMM), enhanced susceptibility in the NOD/Nck H subline was unambiguously attributed to a recessive allele of Dusp10 which encodes a dual specificity phosphatase. The causative effect of the mutation was verified with a high level of confidence by targeting Dusp10 with CRISPR/Cas9 in NOD/Nck L mice: in these animals a higher incidence of diabetes was observed. Expression of wild-type Dusp10 correlated with higher levels of surface PD-L1 in the islets of NOD/Nck L mice.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2021,"id":222835,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9529,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":824089,"name":"Sophie Candon","orcid":"0000-0001-7060-2275","position":1,"is_corresponding":false},{"id":383986,"name":"Sara Hildebrand","orcid":"0000-0002-5534-3604","position":2,"is_corresponding":false},{"id":824519,"name":"Cindy Marquet","orcid":null,"position":3,"is_corresponding":false},{"id":824520,"name":"Fabrice Valette","orcid":null,"position":4,"is_corresponding":false},{"id":790440,"name":"Coralie Pecquet","orcid":null,"position":5,"is_corresponding":false},{"id":824521,"name":"Sébastien Lemoine","orcid":null,"position":6,"is_corresponding":false},{"id":486174,"name":"Francina Langa Vives","orcid":"0000-0002-0801-5464","position":7,"is_corresponding":false},{"id":758666,"name":"Michaël Dumas","orcid":"0000-0001-8527-7006","position":8,"is_corresponding":false},{"id":824090,"name":"Peipei Hu","orcid":"0000-0003-1255-533X","position":9,"is_corresponding":false},{"id":824091,"name":"Pere Santamaría","orcid":"0000-0003-3469-1586","position":10,"is_corresponding":false},{"id":366407,"name":"Stephen Lyon","orcid":"0000-0002-6198-3827","position":11,"is_corresponding":false},{"id":383987,"name":"Lindsay Scott","orcid":"0000-0003-4243-4010","position":12,"is_corresponding":false},{"id":383989,"name":"Chun Hui Bu","orcid":"0000-0002-6210-9875","position":13,"is_corresponding":false},{"id":236562,"name":"Tao Wang","orcid":"0000-0002-4355-149X","position":14,"is_corresponding":false},{"id":383988,"name":"Darui Xu","orcid":"0000-0003-1117-966X","position":15,"is_corresponding":false},{"id":364918,"name":"Eva Marie Y. Moresco","orcid":"0000-0002-2049-7291","position":16,"is_corresponding":false},{"id":824092,"name":"Claudio Scazzocchio","orcid":"0000-0001-8800-2534","position":17,"is_corresponding":false},{"id":824093,"name":"Jean‐François Bach","orcid":"0000-0002-1282-6067","position":18,"is_corresponding":false},{"id":51949,"name":"Bruce Beutler","orcid":"0000-0002-3639-246X","position":19,"is_corresponding":false},{"id":789915,"name":"Lucienne Chatenoud","orcid":"0000-0002-1328-2786","position":20,"is_corresponding":false},{"id":789914,"name":"Anne‐Perrine Foray","orcid":"0000-0002-7718-8473","position":0,"is_corresponding":true}],"reference_count":22,"raw_metadata":null,"created_at":"2026-07-18T23:54:07.287704Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}