{"doi":"10.1101/2020.12.30.424745","title":"Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates","abstract":"Development of an effective AIDS vaccine remains a challenge. Nucleoside-modified mRNAs formulated in lipid nanoparticles (mRNA-LNP) have proved to be a potent mode of immunization against infectious diseases in preclinical studies, and are being tested for SARS-CoV-2 in humans. A critical question is how mRNA-LNP vaccine immunogenicity compares to that of traditional adjuvanted protein vaccines in primates. Here, we found that mRNA-LNP immunization compared to protein immunization elicited either the same or superior magnitude and breadth of HIV-1 Env-specific polyfunctional antibodies. Immunization with mRNA-LNP encoding Zika premembrane and envelope (prM-E) or HIV-1 Env gp160 induced durable neutralizing antibodies for at least 41 weeks. Doses of mRNA-LNP as low as 5 μg were immunogenic in macaques. Thus, mRNA-LNP can be used to rapidly generate single or multi-component vaccines, such as sequential vaccines needed to protect against HIV-1 infection. Such vaccines would be as or more immunogenic than adjuvanted recombinant protein vaccines in primates.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":119220,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9508,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":54904,"name":"Norbert Pardi","orcid":"0000-0003-1008-6242","position":1,"is_corresponding":false},{"id":230383,"name":"Robert Parks","orcid":"0000-0002-6259-7610","position":2,"is_corresponding":false},{"id":231972,"name":"Sampa Santra","orcid":"0000-0002-8796-1714","position":3,"is_corresponding":false},{"id":230382,"name":"Zekun Mu","orcid":"0000-0003-4093-8346","position":4,"is_corresponding":false},{"id":231971,"name":"Laura L. Sutherland","orcid":"0000-0003-4119-3884","position":5,"is_corresponding":false},{"id":469213,"name":"Richard M. Scearce","orcid":"0000-0002-6361-3758","position":6,"is_corresponding":false},{"id":469212,"name":"Maggie Barr","orcid":"0000-0002-0408-0728","position":7,"is_corresponding":false},{"id":553750,"name":"Amanda Eaton","orcid":"0000-0003-3064-2947","position":8,"is_corresponding":false},{"id":553751,"name":"Giovanna E. Hernandez","orcid":"0000-0001-5498-3469","position":9,"is_corresponding":false},{"id":554915,"name":"Derrick Goodman","orcid":null,"position":10,"is_corresponding":false},{"id":230176,"name":"Michael J. Hogan","orcid":"0000-0002-6244-2993","position":11,"is_corresponding":false},{"id":230385,"name":"István Tombácz","orcid":"0000-0001-6683-7223","position":12,"is_corresponding":false},{"id":553752,"name":"David Gordon","orcid":"0000-0002-9593-1590","position":13,"is_corresponding":false},{"id":343910,"name":"Wes Rountree","orcid":"0000-0001-5183-6949","position":14,"is_corresponding":false},{"id":343909,"name":"Yunfei Wang","orcid":"0009-0009-3767-4838","position":15,"is_corresponding":false},{"id":4374,"name":"Mark G. Lewis","orcid":"0000-0001-7852-0135","position":16,"is_corresponding":false},{"id":106870,"name":"Theodore C. Pierson","orcid":"0000-0002-3795-4348","position":17,"is_corresponding":false},{"id":554916,"name":"Chris Barbosa","orcid":null,"position":18,"is_corresponding":false},{"id":54908,"name":"Ying K. Tam","orcid":"0000-0002-4083-5251","position":19,"is_corresponding":false},{"id":332540,"name":"Xiaoying Shen","orcid":"0000-0002-8387-3952","position":20,"is_corresponding":false},{"id":249714,"name":"Guido Ferrari","orcid":"0000-0001-7747-3349","position":21,"is_corresponding":false},{"id":258351,"name":"Georgia D. Tomaras","orcid":"0000-0001-8076-1931","position":22,"is_corresponding":false},{"id":103755,"name":"David C. Montefiori","orcid":"0000-0003-0856-6319","position":23,"is_corresponding":false},{"id":20753,"name":"Drew Weissman","orcid":"0000-0002-1501-6510","position":24,"is_corresponding":false},{"id":96347,"name":"Barton F. Haynes","orcid":"0000-0002-7643-9023","position":25,"is_corresponding":false},{"id":230387,"name":"Kevin O. Saunders","orcid":"0000-0001-7399-7954","position":0,"is_corresponding":true}],"reference_count":89,"raw_metadata":null,"created_at":"2026-07-18T23:14:08.313144Z","pmid":"33398289","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}