{"doi":"10.1101/2020.12.24.424370","title":"Risk-related decision making evokes distinct brain activation patterns in reward evaluation regions in substance use naïve versus non-naïve adolescents","abstract":"ABSTRACT Identifying brain and behavioral precursors to substance use (SU) may guide interventions that delay initiation in youth at risk for SU disorders (SUD). Heightened reward-sensitivity and risk-taking may confer risk for SUD. In a longitudinal, prospective study, we characterized behavioral and neural profiles associated with reward-sensitivity and risk-taking in substance-naïve adolescents, examining whether they differed as a function of SU initiation at 18- and 36-months follow-up. Adolescents ( N =70; 11.1-14.0 years) completed a reward-related decision-making task (Wheel of Fortune (WOF)) while undergoing functional MRI. Measures of reward sensitivity (Behavioral Inhibition System-Behavioral Approach System; BIS-BAS), impulsive decision-making (delay discounting task), and SUD risk (Drug Use Screening Inventory, Revised (DUSI-R)) were collected at baseline. Baseline metrics were compared for youth who did (SI; n =27) and did not (SN; n =43) initiate SU at follow-up. While groups displayed similar discounting and risk taking behavior, SI youth showed more variable patterns of activation in left insular cortex during high-risk selections, and left anterior cingulate cortex in response to rewarded outcomes. SI participants scored higher on the DUSI-R and BAS subscales. Results suggest differences in brain regions critical in the development and experience of SUDs may precede SU and serve as a biomarker for SUD risk.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":132028,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9507,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":270256,"name":"Valerie L. Darcey","orcid":"0000-0002-5053-4567","position":1,"is_corresponding":false},{"id":587476,"name":"Amanda E. Patterson","orcid":null,"position":2,"is_corresponding":false},{"id":433894,"name":"Emma J. Rose","orcid":"0000-0001-5365-4794","position":3,"is_corresponding":false},{"id":325389,"name":"John W. VanMeter","orcid":"0000-0002-7012-5197","position":4,"is_corresponding":false},{"id":586960,"name":"Diana Fishbein","orcid":"0000-0003-1644-2762","position":5,"is_corresponding":false},{"id":586959,"name":"Goldie A. McQuaid","orcid":"0000-0003-3614-616X","position":0,"is_corresponding":true}],"reference_count":146,"raw_metadata":null,"created_at":"2026-07-18T23:16:07.542484Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}