{"doi":"10.1101/2020.12.14.20248192","title":"A Comprehensive Clinical Description of Pediatric SARS-CoV-2 Infection in Western Pennsylvania","abstract":"Objective: We sought to characterize clinical presentation and healthcare utilization for pediatric COVID-19 in Western Pennsylvania (PA). Methods: We established and analyzed a registry of pediatric COVID-19 in Western PA that includes cases in patients <22 years of age cared for by the pediatric quaternary medical center in the area and its associated pediatric primary care network from March 11 through August 20, 2020. Results: Our cohort included 424 pediatric COVID-19 cases (mean age 12.5 years, 47.4% female); 65% reported exposure and 79% presented with symptoms. The most common initial healthcare contact was through telehealth (45%). Most cases were followed as outpatients, but twenty-two patients (4.5%) were hospitalized: 19 with acute COVID-19 disease, and three for multisystem inflammatory syndrome of children (MIS-C). Admitted patients were younger (p<0.001) and more likely to have pre-existing conditions (p<0.001). Black/Hispanic patients were 5.8 times more likely to be hospitalized than white patients (p=0.012). Five patients (1.2%) were admitted to the PICU, including all three MIS-C cases; two required BiPAP and one mechanical ventilation. All patients survived. Conclusions: We provide a comprehensive snapshot of pediatric COVID-19 disease in an area with low to moderate incidence. In this cohort, COVID-19 was generally a mild disease; however, ~5% of children were hospitalized. Pediatric patients can be critically ill with this infection, including those presenting with MIS-C.","journal":"medRxiv","year":2020,"id":120584,"datarank":0.5227216584980054,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"self_citation_contribution":0.3596842909197557,"citation_network_contribution":0.1630373675782498,"self_endowment_contribution":0.3596842909197557,"citer_contribution":0.1630373675782498,"corpus_percentile":62.96897965498569,"corpus_rank":4788,"citation_count":10,"citer_count":6,"citers_with_citation_signal":4,"citers_with_endowment":4,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.8798,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":558540,"name":"K.M. Gaietto","orcid":"0000-0002-4618-2984","position":1,"is_corresponding":false},{"id":559663,"name":"Leigh Anne DiCicco","orcid":null,"position":2,"is_corresponding":false},{"id":559664,"name":"Sherry Rauenswinter","orcid":null,"position":3,"is_corresponding":false},{"id":559665,"name":"Joseph R Squire","orcid":null,"position":4,"is_corresponding":false},{"id":558541,"name":"Zachary Aldewereld","orcid":"0000-0003-4367-9036","position":5,"is_corresponding":false},{"id":558542,"name":"Glenn J. Rapsinski","orcid":"0000-0003-4545-966X","position":6,"is_corresponding":false},{"id":558543,"name":"Jennifer Iagnemma","orcid":"0000-0003-1705-7313","position":7,"is_corresponding":false},{"id":558544,"name":"Brian T. Campfield","orcid":"0000-0002-5380-9837","position":8,"is_corresponding":false},{"id":558545,"name":"David Wolfson","orcid":"0000-0002-3185-4610","position":9,"is_corresponding":false},{"id":456459,"name":"Traci M. Kazmerski","orcid":"0000-0002-3916-8260","position":10,"is_corresponding":false},{"id":277431,"name":"Erick Forno","orcid":"0000-0001-6497-9885","position":11,"is_corresponding":false},{"id":521847,"name":"Megan Culler Freeman","orcid":"0000-0003-3389-6731","position":0,"is_corresponding":true}],"reference_count":23,"raw_metadata":null,"created_at":"2026-07-18T23:14:38.147936Z","pmid":"33354687","pmcid":"PMC7755149","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}