{"doi":"10.1101/2020.12.08.416636","title":"Persistent Cellular Immunity to SARS-CoV-2 Infection","abstract":"Abstract SARS-CoV-2 is responsible for an ongoing pandemic that affected millions of individuals around the globe. To gain further understanding of the immune response in recovered individuals we measured T cell responses in paired samples obtained an average of 1.3 and 6.1 months after infection from 41 individuals. The data indicate that recovered individuals show persistent polyfunctional SARS-CoV-2 antigen specific memory that could contribute to rapid recall responses. In addition, recovered individuals show enduring immune alterations in relative numbers of CD4 + and CD8 + T cells, expression of activation/exhaustion markers, and cell division. Summary We show that SARS-CoV-2 infection elicits broadly reactive and highly functional memory T cell responses that persist 6 months after infection. In addition, recovered individuals show enduring immune alterations in CD4 + and CD8 + T cells compartments.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":119055,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":30,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9533,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":104725,"name":"Pilar Mendoza","orcid":"0000-0003-2957-1811","position":1,"is_corresponding":false},{"id":104711,"name":"Thomas Hägglöf","orcid":"0000-0002-7751-0928","position":2,"is_corresponding":false},{"id":104712,"name":"Thiago Y. Oliveira","orcid":"0000-0002-2654-0879","position":3,"is_corresponding":false},{"id":552810,"name":"Dennis Schaefer-Babajew","orcid":"0000-0002-5380-2950","position":4,"is_corresponding":false},{"id":104704,"name":"Christian Gaebler","orcid":"0000-0001-7295-8128","position":5,"is_corresponding":false},{"id":552811,"name":"Martina Turroja","orcid":"0000-0001-9640-0559","position":6,"is_corresponding":false},{"id":104714,"name":"Arlene Hurley","orcid":"0000-0003-0575-0233","position":7,"is_corresponding":false},{"id":104739,"name":"Marina Caskey","orcid":"0000-0003-1727-8693","position":8,"is_corresponding":false},{"id":104187,"name":"Michel C. Nussenzweig","orcid":"0000-0003-0592-8564","position":9,"is_corresponding":false},{"id":552809,"name":"Gaëlle Breton","orcid":"0000-0003-3540-9378","position":0,"is_corresponding":true}],"reference_count":53,"raw_metadata":null,"created_at":"2026-07-18T23:14:03.409507Z","pmid":"33330867","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}