{"doi":"10.1101/2020.12.08.388942","title":"Indoxyl sulfate, a gut microbiome-derived uremic toxin, is associated with psychic anxiety and its functional magnetic resonance imaging-based neurologic signature","abstract":"ABSTRACT Background It is unknown whether indoles, metabolites of tryptophan that are derived entirely from bacterial metabolism in the gut, are associated with symptoms of depression and anxiety. Methods Serum samples (baseline, 12 weeks) were drawn from participants (n=196) randomized to treatment with cognitive behavioral therapy (CBT), escitalopram, or duloxetine for major depressive disorder. Results Baseline indoxyl sulfate abundance was positively correlated with severity of psychic anxiety and total anxiety and with resting state functional connectivity to a network that processes aversive stimuli (which includes the subcallosal cingulate cortex (SCC-FC), bilateral anterior insula, right anterior midcingulate cortex, and the right premotor areas). The relation between indoxyl sulfate and psychic anxiety was mediated only through the metabolite’s effect on the SCC-FC with the premotor area. Baseline indole abundances were unrelated to post-treatment outcome measures, which suggests that CBT and antidepressant medications relieve anxiety via mechanisms unrelated to gut microbiota. Conclusions A peripheral gut microbiome-derived metabolite was associated with altered neural processing and with psychiatric symptom (anxiety) in humans, which provides further evidence that gut microbiome disruption can contribute to neuropsychiatric disorders that may require different therapeutic approaches.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":125679,"datarank":0.21522119601988415,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.05042935271966769,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.05042935271966769,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":2,"citers_with_citation_signal":1,"citers_with_endowment":1,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9433,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":6363,"name":"Oliver Fiehn","orcid":"0000-0002-6261-8928","position":1,"is_corresponding":false},{"id":58337,"name":"Helen S. Mayberg","orcid":"0000-0002-1672-2716","position":2,"is_corresponding":false},{"id":572427,"name":"Henry L. Schreiber","orcid":"0000-0002-4501-9886","position":3,"is_corresponding":false},{"id":573117,"name":"Siamak Mahmoudian Dehkordi","orcid":null,"position":4,"is_corresponding":false},{"id":245215,"name":"Sudeepa Bhattacharyya","orcid":"0000-0003-3493-6029","position":5,"is_corresponding":false},{"id":275270,"name":"Jungho Cha","orcid":"0000-0003-1189-2051","position":6,"is_corresponding":false},{"id":572428,"name":"Ki Sueng Choi","orcid":"0000-0002-6446-0677","position":7,"is_corresponding":false},{"id":58338,"name":"W. Edward Craighead","orcid":"0000-0001-9957-0027","position":8,"is_corresponding":false},{"id":88836,"name":"Ranga Krishnan","orcid":"0000-0002-3661-8449","position":9,"is_corresponding":false},{"id":69367,"name":"A. John Rush","orcid":"0000-0003-2004-2382","position":10,"is_corresponding":false},{"id":58339,"name":"Boadie W. Dunlop","orcid":"0000-0002-4653-0483","position":11,"is_corresponding":false},{"id":75183,"name":"Rima Kaddurah‐Daouk","orcid":"0000-0003-1858-5732","position":12,"is_corresponding":false},{"id":385342,"name":"Christopher R. Brydges","orcid":"0000-0001-5901-638X","position":0,"is_corresponding":true}],"reference_count":71,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:15:19.482428Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}