{"doi":"10.1101/2020.12.01.407015","title":"Shared B cell memory to coronaviruses and other pathogens varies in human age groups and tissues","abstract":"Abstract Vaccination and infection promote the formation, tissue distribution, and clonal evolution of B cells encoding humoral immune memory. We evaluated convergent antigen-specific antibody genes of similar sequences shared between individuals in pediatric and adult blood, and deceased organ donor tissues. B cell memory varied for different pathogens. Polysaccharide antigen-specific clones were not exclusive to the spleen. Adults’ convergent clones often express mutated IgM or IgD in blood and are class-switched in lymphoid tissues; in contrast, children have abundant class-switched convergent clones in blood. Consistent with serological reports, pre-pandemic children had class-switched convergent clones to SARS-CoV-2, enriched in cross-reactive clones for seasonal coronaviruses, while adults showed few such clones in blood or lymphoid tissues. These results extend age-related and anatomical mapping of human humoral pathogen-specific immunity. One Sentence Summary Children have elevated frequencies of pathogen-specific class-switched memory B cells, including SARS-CoV-2-binding clones.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":121810,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9545,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":237490,"name":"Sandra C. A. Nielsen","orcid":"0000-0003-4746-8287","position":1,"is_corresponding":false},{"id":237493,"name":"Ramona A. Hoh","orcid":"0000-0002-5116-1942","position":2,"is_corresponding":false},{"id":237495,"name":"Ji-Yeun Lee","orcid":"0000-0002-0463-6802","position":3,"is_corresponding":false},{"id":226835,"name":"Tho D. Pham","orcid":"0000-0002-5900-0289","position":4,"is_corresponding":false},{"id":237492,"name":"Katherine Jackson","orcid":"0000-0002-9952-7069","position":5,"is_corresponding":false},{"id":53910,"name":"Krishna M. Roskin","orcid":"0000-0002-5864-5093","position":6,"is_corresponding":false},{"id":480448,"name":"Yi Liu","orcid":"0000-0002-6592-9262","position":7,"is_corresponding":false},{"id":456410,"name":"Robert S. Ohgami","orcid":"0000-0003-1881-3440","position":8,"is_corresponding":false},{"id":562545,"name":"Eleanor M. Osborne","orcid":null,"position":9,"is_corresponding":false},{"id":452818,"name":"Claus U. Niemann","orcid":"0000-0003-3701-6084","position":10,"is_corresponding":false},{"id":231939,"name":"Julie Parsonnet","orcid":"0000-0001-7342-5366","position":11,"is_corresponding":false},{"id":226844,"name":"Scott D. Boyd","orcid":"0000-0003-0963-044X","position":12,"is_corresponding":false},{"id":237491,"name":"Fan Yang","orcid":"0000-0003-4821-6583","position":0,"is_corresponding":true}],"reference_count":45,"raw_metadata":null,"created_at":"2026-07-18T23:14:46.979435Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}