{"doi":"10.1101/2020.11.30.404947","title":"Towards Inferring Nanopore Sequencing Ionic Currents from Nucleotide Chemical Structures","abstract":"ABSTRACT The characteristic ionic currents of nucleotide kmers are commonly used in analyzing nanopore sequencing readouts. We present a graph convolutional network-based deep learning framework for predicting kmer characteristic ionic currents from corresponding chemical structures. We show such a framework can generalize the chemical information of the 5-methyl group from thymine to cytosine by correctly predicting 5-methylcytosine-containing DNA 6mers, thus shedding light on the de novo detection of nucleotide modifications.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":125646,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9452,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":572356,"name":"Ioannis N. Anastopoulos","orcid":"0000-0002-6279-0648","position":1,"is_corresponding":false},{"id":491709,"name":"Andrew D. Bailey","orcid":"0000-0001-8304-7565","position":2,"is_corresponding":false},{"id":266953,"name":"Joshua M. Stuart","orcid":"0000-0002-2171-565X","position":3,"is_corresponding":false},{"id":108063,"name":"Benedict Paten","orcid":"0000-0001-8863-3539","position":4,"is_corresponding":false},{"id":491708,"name":"Hongxu Ding","orcid":"0000-0002-7846-9744","position":0,"is_corresponding":true}],"reference_count":23,"raw_metadata":null,"created_at":"2026-07-18T23:15:19.482428Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}