{"doi":"10.1101/2020.11.30.404624","title":"A Neutralizing Antibody-Conjugated Photothermal Nanoparticle Captures and Inactivates SARS-CoV-2","abstract":"The outbreak of 2019 coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in a global pandemic. Despite intensive research including several clinical trials, currently there are no completely safe or effective therapeutics to cure the disease. Here we report a strategy incorporating neutralizing antibodies conjugated on the surface of a photothermal nanoparticle to actively capture and inactivate SARS-CoV-2. The photothermal nanoparticle is comprised of a semiconducting polymer core and a biocompatible polyethylene glycol surface decorated with neutralizing antibodies. Such nanoparticles displayed efficient capture of SARS-CoV-2 pseudoviruses, excellent photothermal effect, and complete inhibition of viral entry into ACE2-expressing host cells via simultaneous blocking and inactivating of the virus. This photothermal nanoparticle is a flexible platform that can be readily adapted to other SARS-CoV-2 antibodies and extended to novel therapeutic proteins, thus providing a broad range of protection against multiple strains of SARS-CoV-2.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":119343,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9489,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":274972,"name":"Aleksander Promiński","orcid":"0000-0002-7673-3820","position":1,"is_corresponding":false},{"id":483103,"name":"Yiliang Lin","orcid":"0000-0001-9403-9464","position":2,"is_corresponding":false},{"id":535242,"name":"Nicholas Ankenbruck","orcid":"0000-0002-1816-7517","position":3,"is_corresponding":false},{"id":497058,"name":"Jillian Rosenberg","orcid":"0000-0002-3440-2695","position":4,"is_corresponding":false},{"id":554103,"name":"Min Chen","orcid":"0000-0002-8900-2285","position":5,"is_corresponding":false},{"id":554104,"name":"Jiuyun Shi","orcid":"0000-0003-1949-0348","position":6,"is_corresponding":false},{"id":109507,"name":"Eugene B. Chang","orcid":"0000-0001-5972-8248","position":7,"is_corresponding":false},{"id":301557,"name":"Pablo Penaloza‐MacMaster","orcid":"0000-0001-9986-4906","position":8,"is_corresponding":false},{"id":274975,"name":"Bozhi Tian","orcid":"0000-0003-0593-0023","position":9,"is_corresponding":false},{"id":497061,"name":"Jun Huang","orcid":"0000-0003-0271-4384","position":10,"is_corresponding":false},{"id":554102,"name":"Xiaolei Cai","orcid":"0000-0001-5389-6574","position":0,"is_corresponding":true}],"reference_count":57,"raw_metadata":null,"created_at":"2026-07-18T23:14:08.313144Z","pmid":"33269351","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}