{"doi":"10.1101/2020.11.25.398255","title":"Molecular and functional architecture of striatal dopamine release sites","abstract":"Abstract Dopamine controls striatal circuit function, but its transmission mechanisms are not well understood. We recently showed that dopamine secretion requires RIM, suggesting that it occurs at active zone-like sites similar to conventional synapses. Here, we establish using a systematic conditional gene knockout approach that Munc13 and Liprin-α, active zone proteins for vesicle priming and release site organization, are important for dopamine secretion. Correspondingly, RIM zinc finger and C 2 B domains, which bind to Munc13 and Liprin-α, respectively, are needed to restore dopamine release in RIM knockout mice. In contrast, and different from conventional synapses, the active zone scaffolds RIM-BP and ELKS, and the RIM domains that bind to them, are expendable. Hence, dopamine release necessitates priming and release site scaffolding by RIM, Munc13, and Liprin-α, but other active zone proteins are dispensable. Our work establishes that molecularly simple but efficient release site architecture mediates fast dopamine exocytosis.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":121036,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9491,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":559590,"name":"Cordelia Imig","orcid":"0000-0001-7351-8706","position":1,"is_corresponding":false},{"id":559591,"name":"Karthik Balakrishnan","orcid":"0000-0001-9356-788X","position":2,"is_corresponding":false},{"id":559592,"name":"Lauren Kershberg","orcid":"0000-0002-5676-4160","position":3,"is_corresponding":false},{"id":425765,"name":"Noa Lipstein","orcid":"0000-0002-0755-5899","position":4,"is_corresponding":false},{"id":560073,"name":"Riikka‐Liisa Uronen","orcid":null,"position":5,"is_corresponding":false},{"id":559593,"name":"Jiexin Wang","orcid":"0000-0003-1697-1242","position":6,"is_corresponding":false},{"id":559594,"name":"Xintong Cai","orcid":"0000-0001-7903-2416","position":7,"is_corresponding":false},{"id":247125,"name":"Fritz Benseler","orcid":"0009-0006-3846-9447","position":8,"is_corresponding":false},{"id":560074,"name":"Jeong Seop Rhee","orcid":null,"position":9,"is_corresponding":false},{"id":559595,"name":"Benjamin H. Cooper","orcid":"0000-0003-2374-9922","position":10,"is_corresponding":false},{"id":284214,"name":"Changliang Liu","orcid":"0000-0002-0915-8408","position":11,"is_corresponding":false},{"id":559596,"name":"Sonja M. Wojcik","orcid":"0009-0007-6106-252X","position":12,"is_corresponding":false},{"id":65564,"name":"Nils Brose","orcid":"0000-0003-0938-8534","position":13,"is_corresponding":false},{"id":247146,"name":"Pascal S. Kaeser","orcid":"0000-0002-1558-1958","position":14,"is_corresponding":false},{"id":302849,"name":"Aditi Banerjee","orcid":"0000-0003-2016-0717","position":0,"is_corresponding":true}],"reference_count":114,"raw_metadata":null,"created_at":"2026-07-18T23:14:38.147936Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}