{"doi":"10.1101/2020.11.18.389130","title":"Precise spatiotemporal control of voltage-gated sodium channels by photocaged saxitoxin","abstract":"Summary Here we report the pharmacologic blockade of voltage-gated sodium ion channels (NaV) by a synthetic saxitoxin derivative affixed to a photocleavable protecting group. We demonstrate that a functionalized saxitoxin (STX-eac) enables exquisite spatiotemporal control of NaV blockade to interrupt action potentials (APs) in dissociated neurons and nerve fiber bundles. The photo-uncaged inhibitor (STX-ea) is a nanomolar potent, reversible binder of NaVs. We use STX-eac to reveal differential susceptibility of myelinated and unmyelinated axons in the corpus callosum to NaV-dependent alterations in AP propagation, with unmyelinated axons preferentially showing reduced AP fidelity under conditions of partial NaV blockade. These results validate STX-eac as a high precision tool for robust photocontrol of neuronal excitability and AP generation.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":127665,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9532,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":577061,"name":"Gabrielle Devienne","orcid":"0000-0002-2204-8043","position":1,"is_corresponding":false},{"id":577062,"name":"Christopher D. Makinson","orcid":"0000-0002-1427-8148","position":2,"is_corresponding":false},{"id":577063,"name":"Allison L. Haynes","orcid":"0000-0003-3193-4028","position":3,"is_corresponding":false},{"id":367682,"name":"John R. Huguenard","orcid":"0000-0002-6950-1191","position":4,"is_corresponding":false},{"id":336181,"name":"J. Du Bois","orcid":"0000-0001-7847-1548","position":5,"is_corresponding":false},{"id":577060,"name":"Anna V. Elleman","orcid":"0000-0002-0312-2172","position":0,"is_corresponding":true}],"reference_count":61,"raw_metadata":null,"created_at":"2026-07-18T23:15:34.966380Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}