{"doi":"10.1101/2020.11.17.387092","title":"Mosaic nanoparticles elicit cross-reactive immune responses to zoonotic coronaviruses in mice","abstract":"Abstract Protection against SARS-CoV-2 and SARS-related emergent zoonotic coronaviruses is urgently needed. We made homotypic nanoparticles displaying the receptor-binding domain (RBD) of SARS-CoV-2 or co-displaying SARS-CoV-2 RBD along with RBDs from animal betacoronaviruses that represent threats to humans (mosaic nanoparticles; 4-8 distinct RBDs). Mice immunized with RBD-nanoparticles, but not soluble antigen, elicited cross-reactive binding and neutralization responses. Mosaic-RBD-nanoparticles elicited antibodies with superior cross-reactive recognition of heterologous RBDs compared to sera from immunizations with homotypic SARS-CoV-2–RBD-nanoparticles or COVID-19 convalescent human plasmas. Moreover, sera from mosaic-RBD–immunized mice neutralized heterologous pseudotyped coronaviruses equivalently or better after priming than sera from homotypic SARS-CoV-2–RBD-nanoparticle immunizations, demonstrating no immunogenicity loss against particular RBDs resulting from co-display. A single immunization with mosaic-RBD-nanoparticles provides a potential strategy to simultaneously protect against SARS-CoV-2 and emerging zoonotic coronaviruses. One sentence summary Nanoparticle strategy for pan-sarbecovirus vaccine 125-character summary for online ToC Immunizing with nanoparticles displaying diverse coronavirus RBDs elicits cross-reactive and neutralizing antibody responses.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":120205,"datarank":0.38474240361923057,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.0,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9547,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":16983,"name":"Priyanthi N.P. Gnanapragasam","orcid":null,"position":1,"is_corresponding":false},{"id":105101,"name":"Yu E. Lee","orcid":"0000-0001-5989-326X","position":2,"is_corresponding":false},{"id":104735,"name":"Pauline R. Hoffman","orcid":"0000-0002-9260-3356","position":3,"is_corresponding":false},{"id":558116,"name":"Susan Ou","orcid":null,"position":4,"is_corresponding":false},{"id":558117,"name":"Leesa M. Kakutani","orcid":null,"position":5,"is_corresponding":false},{"id":16970,"name":"Jennifer R. Keeffe","orcid":"0000-0002-5317-6398","position":6,"is_corresponding":false},{"id":558118,"name":"Hung-Jen Wu","orcid":null,"position":7,"is_corresponding":false},{"id":419725,"name":"Mark Howarth","orcid":"0000-0001-8870-7147","position":8,"is_corresponding":false},{"id":104736,"name":"Anthony P. West","orcid":"0000-0003-4213-5184","position":9,"is_corresponding":false},{"id":16968,"name":"Christopher O. Barnes","orcid":"0000-0003-2754-5951","position":10,"is_corresponding":false},{"id":104187,"name":"Michel C. Nussenzweig","orcid":"0000-0003-0592-8564","position":11,"is_corresponding":false},{"id":17000,"name":"Pamela J. Björkman","orcid":"0000-0002-2277-3990","position":12,"is_corresponding":false},{"id":16982,"name":"Alexander A. Cohen","orcid":"0000-0002-2818-656X","position":0,"is_corresponding":true}],"reference_count":56,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:14:33.640077Z","pmid":"33236016","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}